Atovaquone
- Generic Name
- Atovaquone
- Brand Names
- Malarone, Mepron
- Drug Type
- Small Molecule
- Chemical Formula
- C22H19ClO3
- CAS Number
- 95233-18-4
- Unique Ingredient Identifier
- Y883P1Z2LT
- Background
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
- Indication
主要用于治疗恶性疟原虫感染（对氯喹敏感或耐药者）；还可用于艾滋病患者合并卡氏肺囊虫病或弓形原虫性脑炎等治疗以及轻中度不能耐受复方磺胺药的肺孢子菌肺炎（PCP肺炎）。
- Associated Conditions
- Malaria caused by Plasmodium falciparum, Pneumocystis Jirovecii Pneumonia, Toxoplasma gondii encephalitis, Acute, uncomplicated Malaria caused by plasmodium falciparum, Mild Babesiosis, Mild Pneumocystis jiroveci pneumonia, Moderate Babesiosis, Moderate Pneumocystis jiroveci pneumonia
An Open-Label, Uncontrolled Clinical Trial of Oral 566C80 for the Treatment of Patients With Severe PCP Who Are Intolerant and/or Unresponsive to Therapy With Trimethoprim/Sulfamethoxazole and Parenteral Pentamidine
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Registration Number
- NCT00001990
- Locations
- 🇺🇸
Glaxo Wellcome Inc, Research Triangle Park, North Carolina, United States
A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Registration Number
- NCT00001991
- Locations
- 🇺🇸
Glaxo Wellcome Inc, Research Triangle Park, North Carolina, United States
A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-03-01
- Target Recruit Count
- 300
- Registration Number
- NCT00000655
- Locations
- 🇺🇸
Georgetown Univ Med Ctr, Washington, District of Columbia, United States
🇺🇸Univ of Cincinnati, Cincinnati, Ohio, United States
🇺🇸Veterans Administration Med Ctr, Washington, District of Columbia, United States
A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 700
- Registration Number
- NCT00000802
- Locations
- 🇺🇸
Case CRS, Cleveland, Ohio, United States
🇺🇸Ucsd, Avrc Crs, San Diego, California, United States
🇺🇸Univ. of Miami AIDS CRS, Miami, Florida, United States
Drug Development Updates
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