Overview
Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Indication
Sunitinib is indicated for the following conditions:
Associated Conditions
- Gastrointestinal Stromal Tumor (GIST)
- Renal Cell Carcinoma (RCC)
- Renal Cell Carcinoma Recurrent
- Unresectable, locally advanced Progressive Neuroendocrine Tumors of pancreatic origin
- Unresectable, metastatic Progressive Neuroendocrine Tumors of pancreatic origin
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2008/06/18 | N/A | Completed | |||
2008/06/18 | Phase 3 | Terminated | |||
2008/06/17 | Phase 2 | Completed | |||
2008/06/11 | Phase 2 | Completed | |||
2008/06/10 | Phase 1 | Completed | |||
2008/06/09 | Phase 3 | Completed | |||
2008/05/26 | N/A | Completed | |||
2008/05/15 | Phase 2 | Completed | Argos Therapeutics | ||
2008/05/13 | Phase 3 | Terminated | |||
2008/05/07 | Phase 1 | Terminated |
FDA Drug Approvals
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HSA Drug Approvals
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Health Canada Drug Approvals
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UK EMC Drug Information
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