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Besifloxacin

Generic Name
Besifloxacin
Brand Names
Besivance
Drug Type
Small Molecule
Chemical Formula
C19H21ClFN3O3
CAS Number
141388-76-3
Unique Ingredient Identifier
BFE2NBZ7NX
Background

Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.

Indication

Treatment of bacterial conjunctivitis. Bacterial isolates that are susceptible to besifloxacin include: CDC coryneform group G; Corynebacterium pseudodiphtheriticum; Corynebacterium striatum; Haemophilus influenzae; Moraxella lacunata; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis; Staphylococcus lugdunensis; Streptococcus mitis group; Streptococcus oralis; Streptococcus pneumoniae; Streptococcus salivarius*

Associated Conditions
Bacterial Conjunctivitis
Clinical Trials
Related News

Effect of Topical Besifloxacin on Ocular Surface Bacterial Microbiota Prior to Cataract Surgery

Phase 1
Completed
Conditions
Cataract Senile
Microbial Disease
Interventions
First Posted Date
2020-09-09
Last Posted Date
2020-09-09
Lead Sponsor
Instituto de Oftalmología Fundación Conde de Valenciana
Target Recruit Count
60
Registration Number
NCT04542759
Locations
🇲🇽

Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico, City, Mexico City, Mexico

Besifloxacin in Bacterial Keratitis

Not Applicable
Completed
Conditions
Bacterial Keratitis
Interventions
First Posted Date
2015-07-14
Last Posted Date
2023-10-19
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
32
Registration Number
NCT02497365
Locations
🇨🇦

McGill Academic Eye Center, Montreal, Quebec, Canada

A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers.

First Posted Date
2013-08-27
Last Posted Date
2015-08-13
Lead Sponsor
Cornea Consultants Of Nashville
Target Recruit Count
2
Registration Number
NCT01928693
Locations
🇺🇸

Cornea Consultants of Nashville, Nashville, Tennessee, United States

Clinical and Microbial Efficacy of Besifloxacin Ophthalmic Suspension, 0.6% in the Treatment of Bacterial Conjunctivitis

Phase 3
Terminated
Conditions
Bacterial Conjunctivitis
Interventions
Drug: Vehicle
First Posted Date
2012-12-04
Last Posted Date
2014-10-01
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
136
Registration Number
NCT01740388
Locations
🇺🇸

Bausch & Lomb Incorporated, Rochester, New York, United States

2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery

Phase 4
Completed
Conditions
Corneal Health
Cataract Surgery
Interventions
First Posted Date
2011-10-19
Last Posted Date
2011-10-19
Lead Sponsor
Ophthalmology Consultants, Ltd.
Target Recruit Count
60
Registration Number
NCT01455233
Locations
🇺🇸

Ophthalmology Associates, St. Louis, Missouri, United States

🇺🇸

Ophthalmology Consultants, Ltd, St. Louis, Missouri, United States

Safety and Efficacy Study of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children

Phase 1
Completed
Conditions
Congenital Nasolacrimal Duct Obstruction
Interventions
First Posted Date
2011-09-09
Last Posted Date
2016-07-14
Lead Sponsor
Rutgers, The State University of New Jersey
Target Recruit Count
24
Registration Number
NCT01431170
Locations
🇺🇸

Institute of Ophthalmology and Visual Science, RUTGERS-New Jersey Medical School, Newark, New Jersey, United States

Besifloxacin Ophthalmic Suspension Verses Gatifloxacin Ophthalmic Solution in Neonates With Bacterial Conjunctivitis

Phase 3
Terminated
Conditions
Bacterial Conjunctivitis
Interventions
First Posted Date
2011-04-06
Last Posted Date
2014-09-03
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
33
Registration Number
NCT01330355
Locations
🇺🇸

Bausch & Lomb Incorporated, Bridgewater, New Jersey, United States

A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery

Phase 4
Completed
Conditions
Cataracts
Interventions
First Posted Date
2011-02-15
Last Posted Date
2020-12-08
Lead Sponsor
Bucci Laser Vision Institute
Target Recruit Count
60
Registration Number
NCT01296542
Locations
🇺🇸

Bucci Laser Vision Institute, Wilkes-Barre, Pennsylvania, United States

Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification

Phase 4
Completed
Conditions
Cataracts
Interventions
First Posted Date
2011-02-15
Last Posted Date
2020-12-22
Lead Sponsor
Frank A. Bucci, Jr., M.D.
Target Recruit Count
120
Registration Number
NCT01296191
Locations
🇺🇸

Bucci Laser Vision Institute, Wilkes-Barre, Pennsylvania, United States

Safety of Besivance™ (Besifloxacin Ophthalmic Suspension) 0.6% Compared to Vehicle

Phase 3
Completed
Conditions
Bacterial Conjunctivitis
Interventions
Drug: Vehicle
First Posted Date
2010-08-05
Last Posted Date
2013-05-01
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
518
Registration Number
NCT01175590
Locations
🇺🇸

Bausch & Lomb, Inc., Rochester, New York, United States

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