Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
Virginia Oncology Associates, Norfolk, Virginia, United States
West Clinic, Germantown, Tennessee, United States
Northwest Cancer Specialists, PC, Vancouver, Washington, United States
University of Colorado, Aurora, Colorado, United States
University of Colorado Cancer Center, Aurora, Colorado, United States
Shandong University Qilu hospital, Jinan, Shandong, China
Xiangya Hospital of Central South University, Changsha, China
1st Hospital Zhejiang University (The First Affiliated Hospital of Zhejiang University ), Hangzhou, China
Shanghai Changzheng Hospital, Shanghai, China
Hackensack University Medical Center, Hackensack, New Jersey, United States
University of California Los Angeles (UCLA), Santa Monica, California, United States
Princess Margaret, Toronto, Ontario, Canada
Department of Anesthesiology, Aarhus University Hospital, Aarhus, Midtjylland, Denmark
Sarah Cannon-Colorado Blood Cancer Institute, Denver, Colorado, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
Swedish Cancer Institute, Seattle, Washington, United States
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
Rady Children's Hospital - San Diego, San Diego, California, United States
Naval Medical Center -San Diego, San Diego, California, United States
Jonnsson Comprehensive Cancer Center / University of Los Angeles, Los Angeles, California, United States
Hackensack University Medical Center / John Therurer Cancer Center, Hackensack, New Jersey, United States
Sylvester, University of Miami, Miami, Florida, United States
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