Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Inhaled Steroids for Acute Pharyngitis.

Phase 2

Completed

Conditions: Acute Pharyngitis

Interventions: Drug: Normal saline
Drug: Budesonide 0.25 MG/ML Inhalant Solution
Drug: Dexamethasone

First Posted Date: 2019-07-19

Last Posted Date: 2022-07-11

Lead Sponsor: Oman Medical Speciality Board

Target Recruit Count: 200

Registration Number: NCT04027322

Locations: 🇴🇲
Armed Forces Hospital, Muscat, Oman
🇴🇲
Mortaafah Armed Medical Hospital (MAM), Muscat, Oman
🇴🇲
Royal Oman Police Hospital, Muscat, Oman

Perioperative Epidural Block and Dexamethasone in Pancreatic Cancer Surgery

Phase 4

Recruiting

Conditions: Pancreatic Cancer
Surgery
Epidural Block
Dexamethasone
Overall Survival

Interventions: Other: Epidural block
Drug: Dexamethasone

First Posted Date: 2019-07-19

Last Posted Date: 2021-07-08

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 260

Registration Number: NCT04025840

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China

Effects of Aprepitant/Dexamethasone Versus Mertazepine /Dexamethasone on Postoperative Nausea and Vomiting

Phase 4

Completed

Conditions: Nausea and Vomiting, Postoperative

Interventions: Drug: Aprepitant and Dexamethasone
Drug: Mirtazapine and Dexamethasone
Drug: Dexamethasone

First Posted Date: 2019-07-09

Last Posted Date: 2020-01-03

Lead Sponsor: Ain Shams University

Target Recruit Count: 90

Registration Number: NCT04013386

Locations: 🇪🇬
Ain-Shams University Hospitals, Cairo, Egypt

Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain

Phase 4

Withdrawn

Conditions: Oral Surgery

Interventions: Drug: Vicodin
Drug: Dexamethasone

First Posted Date: 2019-07-05

Last Posted Date: 2019-11-13

Lead Sponsor: Boston University

Registration Number: NCT04008043

Locations: 🇺🇸
Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, United States

Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM

Phase 2

Active, not recruiting

Conditions: Myeloma, Multiple

Interventions: Drug: Lenalidomide
Drug: Ixazomib
Drug: Daratumumab Injection
Drug: Dexamethasone

First Posted Date: 2019-07-05

Last Posted Date: 2024-02-05

Lead Sponsor: Alliance Foundation Trials, LLC.

Target Recruit Count: 79

Registration Number: NCT04009109

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Dana Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸
Northern Light Eastern Maine Medical Center, Bangor, Maine, United States

and more 4 locations

Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases

Phase 2

Conditions: Brain Metastases
Melanoma
Lung Cancer
Breast Cancer

Interventions: Drug: Dexamethasone
Drug: Metformin

First Posted Date: 2019-06-28

Last Posted Date: 2019-11-13

Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Target Recruit Count: 110

Registration Number: NCT04001725

Locations: 🇮🇹
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Glycyrrhetinic Acid Combined With Dexamethasone in Management of Newly Diagnosed ITP

Phase 4

Conditions: Immune Thrombocytopenia

Interventions: Drug: Dexamethasone
Drug: Glycyrrhetinic Acid

First Posted Date: 2019-06-26

Last Posted Date: 2021-06-11

Lead Sponsor: Shandong University

Target Recruit Count: 30

Registration Number: NCT03998982

Locations: 🇨🇳
Qilu hospital, Shandong University, Jinan, Shandong, China

The Effect of Epidural Steroid Use in Patients With Continous Epidural Block in PHN Patients.

Phase 4

Conditions: Neuralgia,Postherpetic

Interventions: Drug: Dexamethasone
Drug: Ropivacaine

First Posted Date: 2019-06-24

Last Posted Date: 2019-06-24

Lead Sponsor: Korea University Guro Hospital

Target Recruit Count: 40

Registration Number: NCT03995563

Locations: 🇰🇷
Kangnam sacred heart hospital, Seoul, Yeongdeungpo-gu, Korea, Republic of

Steroids and Pain Control After Tonsillectomy

Phase 2

Recruiting

Conditions: Obstructive Sleep Apnea of Child
Tonsillitis

Interventions: Drug: Dexamethasone
Drug: Placebo

First Posted Date: 2019-06-24

Last Posted Date: 2024-11-11

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 150

Registration Number: NCT03995628

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

Phase 1

Active, not recruiting

Conditions: Multiple Myeloma

Interventions: Drug: CC-92480
Drug: Dexamethasone
Drug: Bortezomib
Drug: Isatuximab
Drug: Carfilzomib
Drug: Elotuzumab
Drug: Daratumumab

First Posted Date: 2019-06-18

Last Posted Date: 2024-11-28

Lead Sponsor: Celgene

Target Recruit Count: 424

Registration Number: NCT03989414

Locations: 🇺🇸
Local Institution - 110, Winston-Salem, North Carolina, United States
🇨🇿
Local Institution - 802, Brno, Czechia
🇨🇿
Local Institution - 801, Ostrava-Poruba, Czechia

and more 46 locations

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