Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

A Trial for Relapsed and Relapsed/Refractory Multiple Myeloma Patients

Phase 2

Active, not recruiting

Conditions: Deletion 17P Syndrome
Multiple Myeloma

Interventions: Drug: Daratumumab
Drug: Pomalidomide
Drug: Dexamethasone

First Posted Date: 2019-10-11

Last Posted Date: 2024-07-22

Lead Sponsor: Fondazione EMN Italy Onlus

Target Recruit Count: 45

Registration Number: NCT04124497

Locations: 🇮🇹
Ospedali Riuniti, Bergamo, Italy
🇮🇹
Istituto Clinico Humanitas, Rozzano, Italy
🇮🇹
Policlinico Universitario di Udine, Udine, Italy

and more 12 locations

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Phase 4

Completed

Conditions: Pain, Acute
Hip Arthropathy
Analgesia
Postoperative Pain

Interventions: Drug: Paracetamol
Drug: Ibuprofen
Drug: Dexamethasone
Drug: Placebo IV
Drug: Placebo oral capsules

First Posted Date: 2019-10-11

Last Posted Date: 2023-06-01

Lead Sponsor: Naestved Hospital

Target Recruit Count: 1060

Registration Number: NCT04123873

Locations: 🇩🇰
Køge Hospital, Køge, Denmark
🇩🇰
Næstved-Slagelse-Ringsted Hospitals, Næstved, Danmark, Denmark
🇩🇰
Gentofte Hospital, Hellerup, Denmark

and more 4 locations

Nivolumab, Ixazomib, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Myeloma

Phase 2

Terminated

Conditions: Relapsed Multiple Myeloma
Refractory Multiple Myeloma

Interventions: Drug: Nivolumab
Drug: Ixazomib
Drug: Dexamethasone
Drug: Cyclophosphamide

First Posted Date: 2019-10-08

Last Posted Date: 2023-08-21

Lead Sponsor: Andrew Yee, MD

Target Recruit Count: 2

Registration Number: NCT04119336

Locations: 🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
🇺🇸
Mass General/North Shore Cancer Center, Danvers, Massachusetts, United States

A Clinical Study of Melphalan Flufenamide (Melflufen) and Dexamethasone for Patients With Immunoglobulin Light Chain (AL) Amyloidosis

Phase 1

Terminated

Conditions: AL Amyloidosis

Interventions: Drug: Melphalan-Flufenamide (Melflufen)
Drug: Dexamethasone

First Posted Date: 2019-10-04

Last Posted Date: 2022-03-28

Lead Sponsor: Oncopeptides AB

Target Recruit Count: 6

Registration Number: NCT04115956

Locations: 🇬🇷
Alexandra General Hospital of Athens, Athen, Greece
🇮🇱
Hadassah University Hospital Ein Kerem, Jerusalem, Israel
🇨🇿
Fakultní Nemocnice Ostrava, Ostrava - Poruba, Czechia

and more 6 locations