Flunarizine
- Generic Name
- Flunarizine
- Drug Type
- Small Molecule
- Chemical Formula
- C26H26F2N2
- CAS Number
- 52468-60-7
- Unique Ingredient Identifier
- R7PLA2DM0J
- Background
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
- Indication
Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
- Associated Conditions
- Severe Migraine
Prospective Exploratory Study on rTMS for Migraine Under the Guidance of MEG
- Conditions
- Migraine Disorders, BrainrTMS Stimulation
- Interventions
- Device: rTMS
- First Posted Date
- 2025-01-28
- Last Posted Date
- 2025-02-11
- Lead Sponsor
- Ruijin Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT06796725
- Locations
- 🇨🇳
Ruijin Hospital, Shanghai, China
Childhood Migraine Treatment Noninvasive Pulsed Radiofrequency vs Flunarizine
- Conditions
- Migraine Disease
- Interventions
- Device: Radiofrequency
- First Posted Date
- 2024-12-31
- Last Posted Date
- 2025-01-13
- Lead Sponsor
- Damla Yürük
- Target Recruit Count
- 60
- Registration Number
- NCT06753825
- Locations
- 🇹🇷
Etlik City Hospital, Ankara, Yenimahalle, Turkey
Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
- Target Recruit Count
- 460
- Registration Number
- NCT06499116
Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis
- Conditions
- MigraineProphylaxis
- Interventions
- First Posted Date
- 2023-12-08
- Last Posted Date
- 2023-12-29
- Lead Sponsor
- Shalamar Institute of Health Sciences
- Target Recruit Count
- 84
- Registration Number
- NCT06162819
- Locations
- 🇵🇰
Shalamar Hospital, Lahore, Punjab, Pakistan
Flunarizine for Treatment Resistant Absence Epilepsy
- Conditions
- Childhood Absence EpilepsyJuvenile Absence EpilepsyJuvenile Myoclonic Epilepsy
- Interventions
- First Posted Date
- 2023-12-01
- Last Posted Date
- 2023-12-01
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 9
- Registration Number
- NCT06153186
- Locations
- 🇨🇦
BC Children's Hospital, Vancouver, British Columbia, Canada
Decoding Pain Sensitivity in Migraine With Multimodal Brainstem-based Neurosignature
- First Posted Date
- 2021-01-11
- Last Posted Date
- 2021-04-14
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 600
- Registration Number
- NCT04702971
- Locations
- 🇨🇳
Headache Center, Teipei Veterans General Hospital, Taipei, Taiwan
Evaluation of Efficacy and Safety of add-on Alpha-lipoic Acid on Migraine Prophylaxis in Adolescent Population
- Conditions
- Adolescent Migraine
- Interventions
- Drug: Alpha lipoic acid 300mg
- First Posted Date
- 2019-08-22
- Last Posted Date
- 2023-07-25
- Lead Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
- Target Recruit Count
- 60
- Registration Number
- NCT04064814
- Locations
- 🇮🇳
AIIMS, Bhubaneswar, Odisha, India
Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2018-10-19
- Last Posted Date
- 2020-01-21
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 120
- Registration Number
- NCT03712917
- Locations
- 🇹🇷
Ataturk University Resarch Hospital, Erzurum, Turkey
Neurologic Signatures of Chronic Pain Disorders
- Conditions
- Chronic PainFibromyalgiaChronic Migraine
- Interventions
- First Posted Date
- 2016-04-22
- Last Posted Date
- 2020-11-02
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 200
- Registration Number
- NCT02747940
- Locations
- 🇨🇳
Headache Center, Teipei Veterans General Hospital, Taipei, Taiwan
Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis
- First Posted Date
- 2015-12-24
- Last Posted Date
- 2015-12-24
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 62
- Registration Number
- NCT02639598
Drug Development Updates
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