Obeticholic acid
- Generic Name
- Obeticholic acid
- Brand Names
- Ocaliva
- Drug Type
- Small Molecule
- Chemical Formula
- C26H44O4
- CAS Number
- 459789-99-2
- Unique Ingredient Identifier
- 0462Z4S4OZ
- Background
Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation.
...
- Indication
用于治疗原发性胆汁性胆管炎(PBC)或用于治疗原发性胆汁性肝硬化（PBC）。
- Associated Conditions
- Primary Biliary Cholangitis
- Associated Therapies
- -
Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Adult Participants
- First Posted Date
- 2021-11-24
- Last Posted Date
- 2022-11-08
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 52
- Registration Number
- NCT05133830
- Locations
- 🇺🇸
GSK Investigational Site, Baltimore, Maryland, United States
Obeticholic Acid for Prevention in Barrett's Esophagus
- Conditions
- Interventions
- First Posted Date
- 2021-06-25
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 30
- Registration Number
- NCT04939051
- Locations
- 🇺🇸
Seidman Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸University of Kansas Cancer Center, Kansas City, Kansas, United States
🇺🇸University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Study of OCA in Combination with BZF Evaluating Efficacy, Safety, and Tolerability in Participants with PBC
- Conditions
- Interventions
- First Posted Date
- 2020-10-20
- Last Posted Date
- 2024-11-04
- Lead Sponsor
- Intercept Pharmaceuticals
- Target Recruit Count
- 72
- Registration Number
- NCT04594694
- Locations
- 🇬🇷
Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece
🇫🇷Hôpital Henri Mondor, Créteil, France
🇩🇪Medizinische Hochschule Hannover, Hannover, Germany
Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2019-08-12
- Last Posted Date
- 2020-07-24
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 19
- Registration Number
- NCT04053023
- Locations
- 🇬🇧
GSK Investigational Site, Cambridge, United Kingdom
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT
- Conditions
- Interventions
- First Posted Date
- 2019-02-11
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Sir Salimullah Medical College Mitford Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT03836937
- Locations
- 🇧🇩
Department of Hepatology, Dhaka, Bangladesh
Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT
- Conditions
- Interventions
- First Posted Date
- 2017-08-17
- Last Posted Date
- 2019-11-01
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 8
- Registration Number
- NCT03253276
- Locations
- 🇩🇰
Susanne Keiding, Aarhus, Denmark
Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL)
- Conditions
- Interventions
- First Posted Date
- 2015-12-17
- Last Posted Date
- 2018-06-04
- Lead Sponsor
- Intercept Pharmaceuticals
- Target Recruit Count
- 84
- Registration Number
- NCT02633956
- Locations
- 🇺🇸
Consultants for Clinical Research, Cincinnati, Ohio, United States
🇺🇸University of Miamai, Schiff Center for Liver Diseases, Miami, Florida, United States
🇺🇸Mercy Medical Center, Institute for Digestive Health & Liver Disease, Baltimore, Maryland, United States
Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment
- Conditions
- Interventions
- First Posted Date
- 2015-09-14
- Last Posted Date
- 2024-10-01
- Lead Sponsor
- Intercept Pharmaceuticals
- Target Recruit Count
- 2477
- Registration Number
- NCT02548351
- Locations
- 🇺🇸
The University of Chicago Medical Center, Chicago, Illinois, United States
🇺🇸Johns Hopkins Hospital, Baltimore, Maryland, United States
🇺🇸Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers
- First Posted Date
- 2015-08-25
- Last Posted Date
- 2020-08-25
- Lead Sponsor
- Sahlgrenska University Hospital, Sweden
- Target Recruit Count
- 40
- Registration Number
- NCT02532335
- Locations
- 🇸🇪
Hanns-Ulrich Marschall, Göteborg, Sweden
🇸🇪Sahlgrenska Academy, Göteborg, Sweden
Phase 2 Study of Obeticholic Acid for Lipodystrophy Patients
- Conditions
- Interventions
- First Posted Date
- 2015-04-29
- Last Posted Date
- 2024-08-27
- Lead Sponsor
- Abhimanyu Garg
- Target Recruit Count
- 10
- Registration Number
- NCT02430077
- Locations
- 🇺🇸
UT Southwestern Medical Center, Dallas, Texas, United States
🇺🇸UT Southwestern Medical Center 5323 Harry Hines Blvd, Dallas, Texas, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.