Obeticholic acid
- Generic Name
- Obeticholic acid
- Brand Names
- Ocaliva
- Drug Type
- Small Molecule
- Chemical Formula
- C26H44O4
- CAS Number
- 459789-99-2
- Unique Ingredient Identifier
- 0462Z4S4OZ
- Background
Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation.
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- Indication
用于治疗原发性胆汁性胆管炎(PBC)或用于治疗原发性胆汁性肝硬化（PBC）。
- Associated Conditions
- Primary Biliary Cholangitis
- Associated Therapies
- -
Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Participants With Primary Biliary Cirrhosis
- First Posted Date
- 2013-05-31
- Last Posted Date
- 2022-08-24
- Lead Sponsor
- Intercept Pharmaceuticals
- Target Recruit Count
- 27
- Registration Number
- NCT01865812
- Locations
- 🇺🇸
McGuire DVAMC, Richmond, Virginia, United States
🇺🇸Beth Israel Medical Center, New York, New York, United States
🇺🇸Scripps Clinic, La Jolla, California, United States
Obeticholic Acid in Bariatric and Gallstone Disease
- First Posted Date
- 2012-06-21
- Last Posted Date
- 2016-10-18
- Lead Sponsor
- Sahlgrenska University Hospital, Sweden
- Target Recruit Count
- 40
- Registration Number
- NCT01625026
- Locations
- 🇸🇪
Hanns-Ulrich Marschall, Göteborg, Sweden
Obeticholic Acid in Bile Acid Diarrhoea
- Conditions
- Interventions
- First Posted Date
- 2012-04-25
- Last Posted Date
- 2023-03-10
- Lead Sponsor
- Imperial College Healthcare NHS Trust
- Target Recruit Count
- 35
- Registration Number
- NCT01585025
- Locations
- 🇬🇧
Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
🇬🇧Hammersmith Hospital, London, United Kingdom
The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial(FLINT)
- Conditions
- Interventions
- First Posted Date
- 2010-12-23
- Last Posted Date
- 2018-04-06
- Target Recruit Count
- 283
- Registration Number
- NCT01265498
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸University of California, San Diego, San Diego, California, United States
Drug Development Updates
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