Lamotrigine

Generic Name
Lamotrigine
Brand Names
Lamictal
Drug Type
Small Molecule
Chemical Formula
C9H7Cl2N5
CAS Number
84057-84-1
Unique Ingredient Identifier
U3H27498KS
Background

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 cou...

Indication

Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome.
...

Associated Conditions
Bipolar 1 Disorder, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Seizures, Generalized
Associated Therapies
Conversion to monotherapy
Clinical Trials
Related News

Drug Use Investigation for LAMICTAL

Completed
Conditions
Epilepsy
Interventions
Drug: Lamotrigine
First Posted Date
2011-06-20
Last Posted Date
2016-11-09
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
3000
Registration Number
NCT01376180

Lamotrigine Bioequivalence Study to Compare Dispersible Tables With Compressed Tablets in China

Phase 1
Completed
Conditions
Epilepsy
Interventions
Drug: Lamotrigine
First Posted Date
2011-05-23
Last Posted Date
2017-09-20
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
24
Registration Number
NCT01357902
Locations
🇭🇰

GSK Investigational Site, Shatin, New Territories, Hong Kong

Reversing Corticosteroid Induced Memory Impairment

Phase 4
Completed
Conditions
Memory Impairment
Interventions
Drug: Placebo
Drug: Lamotrigine
First Posted Date
2010-06-11
Last Posted Date
2018-08-27
Lead Sponsor
University of Texas Southwestern Medical Center
Target Recruit Count
54
Registration Number
NCT01142310
Locations
🇺🇸

Parkland Health and Hospital System (Asthma, Allergy, & Arthritis Clinics), Dallas, Texas, United States

Bioequivalence Study of Lamotrigine 25 mg Chewable Tablets of Dr.Reddy's Under Fasting Condition

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Lamotrigine
First Posted Date
2010-05-27
Last Posted Date
2010-06-14
Lead Sponsor
Dr. Reddy's Laboratories Limited
Target Recruit Count
26
Registration Number
NCT01131949
Locations
🇺🇸

AAI Clinic, Chapel Hill, North Carolina, United States

Bioequivalence Study of Lamotrigine 25 mg Chewable Tablets of Dr.Reddy's Under Fed Condition

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Lamotrigine
First Posted Date
2010-05-27
Last Posted Date
2010-06-14
Lead Sponsor
Dr. Reddy's Laboratories Limited
Target Recruit Count
26
Registration Number
NCT01131975
Locations
🇺🇸

AAI Clinic, Chapel Hill, North Carolina, United States

Bipolar Depression Before and After Lamotrigine Treatment

Phase 3
Completed
Conditions
Bipolar Depression
Interventions
Drug: Lamotrigine
Procedure: 1H-MR
First Posted Date
2010-01-05
Last Posted Date
2016-02-08
Lead Sponsor
Mayo Clinic
Target Recruit Count
72
Registration Number
NCT01042496
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Treatment of Alcohol Dependence and Comorbid Bipolar Disorder

First Posted Date
2009-11-18
Last Posted Date
2019-01-09
Lead Sponsor
Medical University of South Carolina
Target Recruit Count
43
Registration Number
NCT01015586
Locations
🇺🇸

Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, United States

Study of Lamotrigine 2 x 25 mg IR Tablets of Torrent Pharmaceuticals Pvt., Ltd., India and Lamictal ® (Lamotrigine) 2 x 25 mg Tablets of Glaxo-SmithKline, USA, in Healthy Human Adult Subjects, Under Fed Conditions

Phase 1
Completed
Conditions
Healthy
First Posted Date
2009-07-15
Last Posted Date
2017-10-25
Lead Sponsor
Torrent Pharmaceuticals Limited
Registration Number
NCT00939458
Locations
🇮🇳

Lotus Labs Pvt. Ltd., Bangalore, Karnataka, India

Study of Lamotrigine 2×25 mg IR Tablets of Torrent Pharmaceuticals Limited, India and Lamictal® (Lamotrigine) 2×25 mg Tablets of GlaxoSmithKline, USA, in Healthy Human Adult Subjects, Under Fasting Conditions.

Phase 1
Completed
Conditions
Healthy
First Posted Date
2009-07-15
Last Posted Date
2017-10-25
Lead Sponsor
Torrent Pharmaceuticals Limited
Registration Number
NCT00939614
Locations
🇮🇳

Lotus Labs Pvt. Ltd., Bangalore, Karnataka, India

The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis

First Posted Date
2009-06-10
Last Posted Date
2009-06-10
Lead Sponsor
Cantonal Hospital of St. Gallen
Target Recruit Count
88
Registration Number
NCT00917839
Locations
🇨🇭

Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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