Vorinostat

Generic Name: Vorinostat

Brand Names: Zolinza

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₂₀N_₂O_₃

CAS Number: 149647-78-9

Unique Ingredient Identifier: 58IFB293JI

Background: Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase...

Indication: 用于治疗加重、持续和复发或用两种全身性药物治疗后无效的T细胞淋巴瘤(CTCL, 一种非霍奇金淋巴瘤)。

Associated Conditions: Cutaneous T-Cell Lymphoma Recurrent, Persistent Cutaneous T-Cell Lymphoma, Progressive Cutaneous T-cell lymphoma

Associated Therapies: -

Clinical Trials

Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia

Phase 3

Completed

Conditions: Acute Myeloid Leukemia
Untreated Adult Acute Myeloid Leukemia

Interventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation
Drug: Cytarabine
Drug: Daunorubicin Hydrochloride
Drug: Idarubicin
Other: Laboratory Biomarker Analysis
Drug: Vorinostat

First Posted Date: 2013-03-01

Last Posted Date: 2018-12-19

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 754

Registration Number: NCT01802333

Locations: 🇺🇸
Flaget Memorial Hospital, Bardstown, Kentucky, United States
🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

and more 443 locations

Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell Transplant

Phase 2

Completed

Conditions: Graft vs Host Disease
Hematologic Neoplasms
Non-Neoplastic Hematologic and Lymphocytic Disorder

Interventions: Drug: Vorinostat
Drug: Tacrolimus
Drug: Methotrexate

First Posted Date: 2013-02-13

Last Posted Date: 2018-08-13

Lead Sponsor: University of Michigan Rogel Cancer Center

Target Recruit Count: 26

Registration Number: NCT01790568

Locations: 🇺🇸
University of Michigan Cancer Center, Ann Arbor, Michigan, United States

Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies

Phase 2

Completed

Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma
Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma
Contiguous Stage II Adult Lymphoblastic Lymphoma
Contiguous Stage II Grade 1 Follicular Lymphoma
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Contiguous Stage II Grade 2 Follicular Lymphoma
Adult Acute Myeloid Leukemia With Del(5q)

Interventions: Drug: vorinostat
Drug: tacrolimus
Drug: cyclosporine
Drug: methotrexate
Other: laboratory biomarker analysis
Other: pharmacological study

First Posted Date: 2013-02-12

Last Posted Date: 2018-07-24

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 12

Registration Number: NCT01789255

Locations: 🇺🇸
University of Michigan University Hospital, Ann Arbor, Michigan, United States

Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients

Phase 2

Completed

Conditions: Adult Brain Tumor
Malignant Glioma
Recurrent Glioblastoma Multiforme

Interventions: Drug: Vorinostat
Drug: Bevacizumab

First Posted Date: 2012-11-30

Last Posted Date: 2017-03-06

Lead Sponsor: Duke University

Target Recruit Count: 48

Registration Number: NCT01738646

Locations: 🇺🇸
Duke Cancer Center, Durham, North Carolina, United States

Study of KW-0761 Versus Vorinostat in Relapsed/Refractory CTCL

Phase 3

Completed

Conditions: Cutaneous T-Cell Lymphoma

Interventions: Biological: KW-0761
Drug: Vorinostat

First Posted Date: 2012-11-20

Last Posted Date: 2024-04-25

Lead Sponsor: Kyowa Kirin, Inc.

Target Recruit Count: 372

Registration Number: NCT01728805

Locations: 🇺🇸
Ohio State University, Columbus, Ohio, United States
🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States

and more 70 locations

Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Hormone Therapy

Not Applicable

Completed

Conditions: Male Breast Cancer
Recurrent Breast Cancer
Stage IV Breast Cancer

Interventions: Drug: vorinostat
Drug: anastrozole
Drug: letrozole
Drug: exemestane
Procedure: positron emission tomography
Radiation: F-18 16 alpha-fluoroestradiol
Radiation: fludeoxyglucose F 18
Other: laboratory biomarker analysis

First Posted Date: 2012-11-02

Last Posted Date: 2020-01-07

Lead Sponsor: University of Washington

Target Recruit Count: 15

Registration Number: NCT01720602

Locations: 🇺🇸
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer

Not Applicable

Withdrawn

Conditions: Stage II Breast Cancer
Stage IIIA Breast Cancer
Triple-negative Breast Cancer

Interventions: Drug: vorinostat
Procedure: therapeutic conventional surgery
Other: laboratory biomarker analysis

First Posted Date: 2012-09-27

Last Posted Date: 2014-01-28

Lead Sponsor: University of Southern California

Registration Number: NCT01695057

Randomised Study of Azacitidine Versus Azacitidine With Vorinostat in Patients With AML or High Risk MDS

Phase 2

Completed

Conditions: Leukemia, Myeloid, Acute

Interventions: Drug: Azacitidine
Drug: Vorinostat

First Posted Date: 2012-06-12

Last Posted Date: 2021-05-05

Lead Sponsor: University of Birmingham

Target Recruit Count: 260

Registration Number: NCT01617226

Locations: 🇬🇧
Barts and the London NHS Trust, London, Greater London, United Kingdom
🇬🇧
Hammersmith Hospital, London, Greater London, United Kingdom
🇬🇧
Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom

and more 10 locations