Basic Information
MALARONE TABLET
TABLET, FILM COATED
Regulatory Information
SIN09761P
May 16, 1998
Prescription Only
Therapeutic
ORAL
August 10, 2023
June 3, 2025
XP01BB51
Company Information
GLAXOSMITHKLINE PTE LTD
GLAXOSMITHKLINE PTE LTD
Active Ingredients
Strength: 100 mg
Strength: 250 mg
Detailed Information
Contraindications
**4.3. Contra-indications** Malarone is contra-indicated in individuals with known hypersensitivity to atovaquone or proguanil hydrochloride or any component of the formulation. Malarone is contra-indicated for prophylaxis of _P. falciparum_ malaria in patients with severe renal impairment (creatinine clearance <30 ml/min).
Indication Information
**4.1. Therapeutic Indications** Malarone is a fixed-dose combination of atovaquone and proguanil hydrochloride which acts as a blood schizonticide. It is indicated for: - Prophylaxis of _Plasmodium falciparum_ malaria. - Treatment of _Plasmodium falciparum_ malaria. Because Malarone is effective against drug sensitive and drug resistant _P. falciparum_ malaria, it is especially recommended for prophylaxis and treatment of _P. falciparum_ malaria in areas where the pathogen may be resistant to other antimalarials. Official guidelines and local information on the prevalence of resistance to antimalarial drugs should be taken into consideration. Official guidelines will normally include WHO and public health authorities’ guidelines.