Alnylam Pharmaceuticals
- Country
- πΊπΈUnited States
- Ownership
- -
- Established
- 2002-01-01
- Employees
- -
- Market Cap
- $35.9B
- Website
- http://www.alnylam.com/
Clinical Trials
77
Trial Phases
4 Phases
Drug Approvals
0
Drug Approvals
No drug approvals found
This company may not have drug approvals in our database
Clinical Trials
Distribution across different clinical trial phases (63 trials with phase data)β’ Click on a phase to view related trials
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
- Conditions
- Hereditary Transthyretin-Mediated Amyloidosis With PolyneuropathyhATTR-PN
- Interventions
- First Posted Date
- 2025-10-31
- Last Posted Date
- 2025-10-31
- Lead Sponsor
- Alnylam Pharmaceuticals
- Target Recruit Count
- 125
- Registration Number
- NCT07223203
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
- Conditions
- Alzheimer's Disease
- Interventions
- Drug: ALN-5288Drug: Placebo
- First Posted Date
- 2025-10-09
- Last Posted Date
- 2025-11-13
- Lead Sponsor
- Alnylam Pharmaceuticals
- Target Recruit Count
- 50
- Registration Number
- NCT07214727
- Locations
- π¬π§
Clinical Trial Site, Southampton, United Kingdom
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
- Conditions
- High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular Risk
- Interventions
- Drug: Placebo
- First Posted Date
- 2025-09-18
- Last Posted Date
- 2025-11-04
- Lead Sponsor
- Alnylam Pharmaceuticals
- Target Recruit Count
- 11000
- Registration Number
- NCT07181109
- Locations
- πΊπΈ
Clinical Trial Site, Bountiful, Utah, United States
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
- Conditions
- Transthyretin Amyloidosis With Cardiomyopathy
- Interventions
- Drug: Sterile Normal Saline (0.9% NaCl)
- First Posted Date
- 2025-07-08
- Last Posted Date
- 2025-11-13
- Lead Sponsor
- Alnylam Pharmaceuticals
- Target Recruit Count
- 1250
- Registration Number
- NCT07052903
- Locations
- πͺπΈ
Clinical Trial Site-1, Valencia, Spain
πͺπΈClinical Trial Site-2, Valencia, Spain
π¬π§Clinical Trial Site, Manchester, United Kingdom
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
- Conditions
- Obese or Overweight Healthy VolunteersType 2 Diabetes Mellitus (T2DM)
- Interventions
- Drug: ALN-4324Drug: Placebo
- First Posted Date
- 2025-02-25
- Last Posted Date
- 2025-11-12
- Lead Sponsor
- Alnylam Pharmaceuticals
- Target Recruit Count
- 144
- Registration Number
- NCT06845202
- Locations
- π΅π±
Clinical Trial Site, Warsaw, Poland
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News
Arrowhead Pharmaceuticals Secures First FDA Approval with Redemplo for Rare Genetic Disorder
The FDA approved Redemplo (plozasiran), Arrowhead Pharmaceuticals' first commercial drug, for treating familial chylomicronemia syndrome in adults as an adjunct to diet.
Acuitas Therapeutics Advances Next-Generation Lipid Nanoparticle Technology with Enhanced Potency and Targeted Delivery
Acuitas Therapeutics presented next-generation lipid nanoparticle (LNP) advancements at the 2025 mRNA Health Conference, featuring novel formulations with up to fourfold improved potency in gene editing and vaccine applications.
Vir Biotechnology to Present 48-Week SOLSTICE Trial Results for Hepatitis Delta Combination Therapy at AASLD 2025
Vir Biotechnology will present Week 48 endpoint results from the Phase 2 SOLSTICE trial evaluating tobevibart alone or in combination with elebsiran for chronic hepatitis delta at AASLD 2025.
Ultragenyx Appoints Eric Olson as Chief Business Officer to Lead Rare Disease Pipeline Expansion
Ultragenyx Pharmaceutical appointed Eric Olson as Chief Business Officer and Executive Vice President effective September 22, 2025, following Thomas Kassberg's planned retirement after 14 years with the company.
Huntington's Disease Pipeline Shows Strong Growth with Over 20 Companies Developing Novel Therapies
Over 20 pharmaceutical and biotech companies are actively developing more than 20 therapeutic candidates for Huntington's disease at various clinical and preclinical stages.
Moderna Settles Patent Dispute with Alnylam Over COVID-19 Vaccine Technology
Moderna has settled patent infringement lawsuits filed by Alnylam Pharmaceuticals over alleged misuse of lipid nanoparticle technology in COVID-19 vaccines.
Alnylam Pharmaceuticals Joins Alliance for Genomic Discovery to Accelerate RNAi Drug Development
Alnylam Pharmaceuticals has joined the Alliance for Genomic Discovery as the ninth member, gaining access to a comprehensive clinical genomic database containing 250,000 whole-genomes to accelerate RNA interference therapeutic development.
Biotech Veterans Launch Corsera Health with Annual RNAi Drug to Prevent Cardiovascular Disease
Biotech leaders John Maraganore and Clive Meanwell have launched Corsera Health with the ambitious goal of creating a world without cardiovascular disease.
Alnylam's Zilebesiran Advances to Phase III ZENITH Trial for Hypertension Treatment
Zilebesiran, developed by Alnylam Pharmaceuticals and Roche, targets angiotensinogen in the renin-angiotensin-aldosterone system and offers biannual dosing for hypertension management.
Delaware Court Rules Pfizer COVID-19 Vaccine Does Not Infringe Alnylam's Nanoparticle Patents
The U.S. District Court for the District of Delaware entered a final judgment on July 30, 2025, ruling that Pfizer's COVID-19 vaccine did not infringe any of Alnylam's patents covering nanoparticle technology.
