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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

πŸ‡ΊπŸ‡ΈUnited States
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COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study

Phase 2
Active, not recruiting
Conditions
Kidney Transplant
COVID-19
Interventions
Biological: Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine
First Posted Date
2022-08-26
Last Posted Date
2025-03-24
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
80
Registration Number
NCT05518487
Locations
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University of California San Diego Medical Center: Transplantation, San Diego, California, United States

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Emory University School of Medicine: Transplantation, Atlanta, Georgia, United States

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UCSF School of Medicine: Transplantation, San Francisco, California, United States

and more 3 locations

Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine

Phase 2
Completed
Conditions
Monkeypox
Interventions
First Posted Date
2022-08-23
Last Posted Date
2025-04-20
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
229
Registration Number
NCT05512949
Locations
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Brigham and Women's Hospital, Boston, Massachusetts, United States

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University of California, San Diego (UCSD) - Antiviral Research Center (AVRC), San Diego, California, United States

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Vanderbilt University Medical Center, Nashville, Tennessee, United States

and more 5 locations

Safety and Immunogenicity of CJCV2 With and Without ALFQ

Phase 1
Completed
Conditions
Campylobacter Infection
Interventions
First Posted Date
2022-08-15
Last Posted Date
2025-01-17
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
59
Registration Number
NCT05500417
Locations
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Cincinnati Children's Hospital Medical Center Vaccine Research Center, Cincinnati, Ohio, United States

Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease (EVD) Survivors in PREVAIL III

Completed
Conditions
Ebola Virus Disease
First Posted Date
2022-08-10
Last Posted Date
2025-03-30
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
203
Registration Number
NCT05494801
Locations
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John F. Kennedy Medical Center, Monrovia, Liberia

A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults

Phase 1
Completed
Conditions
HIV
Interventions
Biological: Trimer 6931 (100 mcg)
Biological: FP conjugate vaccine (200 mcg)
Biological: FP conjugate vaccine (25 mcg)
Biological: Trimer 4571 (200 mcg)
Biological: Trimer 6931 (200 mcg)
Biological: Trimer 4571 (100 mcg)
First Posted Date
2022-07-22
Last Posted Date
2025-03-21
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
44
Registration Number
NCT05470400
Locations
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BIDMC Vcrs [32077], Boston, Massachusetts, United States

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New York Blood Center CRS [31801], New York, New York, United States

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Atlanta - Hope Clinic, Atlanta, Georgia, United States

and more 3 locations

Trial to Evaluate the Safety and Immunogenicity of Priming Regimens of 426c.Mod.Core-C4b Adjuvanted With 3M-052-AF + Alum in Healthy, HIV-1 Uninfected Adult Participants

Phase 1
Active, not recruiting
Conditions
HIV-1-infection
Interventions
Biological: 426c.Mod.Core-C4b 30 mcg
Other: Placebo
Biological: BG505
Biological: 426c.Mod.Core-C4b 100 mcg
Biological: 426c.Mod.Core-C4b 300 mcg
First Posted Date
2022-07-22
Last Posted Date
2023-11-30
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
52
Registration Number
NCT05471076
Locations
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Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston, Massachusetts, United States

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Bridge HIV CRS, San Francisco, California, United States

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Seattle Vaccine and Prevention CRS, Seattle, Washington, United States

and more 3 locations

Neonatal Phase 1 Valacyclovir Study

Phase 1
Recruiting
Conditions
Herpes Simplex
Interventions
First Posted Date
2022-07-21
Last Posted Date
2025-05-23
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
16
Registration Number
NCT05468619
Locations
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Children's Nebraska, Omaha, Nebraska, United States

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Nationwide Children's Hospital, Columbus, Ohio, United States

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Children's of Alabama Child Health Research Unit (CHRU), Birmingham, Alabama, United States

and more 9 locations

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Phase 1
Recruiting
Conditions
Chronic Granulomatous Disease
Interventions
Biological: Pheripheral blood stem cells
Drug: Tociluzumab
Drug: Emapalumab-Izsg
Drug: Total Body Irradiation
First Posted Date
2022-07-18
Last Posted Date
2025-05-20
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
50
Registration Number
NCT05463133
Locations
πŸ‡ΊπŸ‡Έ

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

Phase 1
Completed
Conditions
Bacterial Disease Carrier
Cystic Fibrosis
Interventions
First Posted Date
2022-07-12
Last Posted Date
2025-04-23
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
72
Registration Number
NCT05453578
Locations
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The University of Arizona - Banner University Medical Center Tucson Campus - Tucson, Tucson, Arizona, United States

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University of California, San Diego, La Jolla, California, United States

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University of California Los Angeles Medical Center - Westwood Clinic, Los Angeles, California, United States

and more 14 locations

Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model

Phase 1
Completed
Conditions
Influenza Infection
Interventions
Biological: A/Mallard/Ohio-99/MM4/1989 H10N7
First Posted Date
2022-06-29
Last Posted Date
2025-03-11
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
35
Registration Number
NCT05436444
Locations
πŸ‡ΊπŸ‡Έ

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

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