NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein

Phase 1

Suspended

Conditions: Ebola Virus Disease

Interventions: Biological: Placebo
Biological: HPIV3/ΔHNF/EbovZ GP vaccine

First Posted Date: 2018-03-12

Last Posted Date: 2024-03-12

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 30

Registration Number: NCT03462004

Locations: 🇺🇸
Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States
🇺🇸
CIR Inpatient Unit, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Evaluation of the Efficacy of the Live Attenuated Tetravalent Dengue Vaccine Against DENV-2 and DENV-3 Challenge

Phase 1

Completed

Conditions: Dengue

Interventions: Biological: rDEN2Δ30-7169 (DENV-2)
Biological: TetraVax-DV-TV003 (TV003)
Biological: Placebo
Biological: rDEN3Δ30 (DENV-3)

First Posted Date: 2018-01-30

Last Posted Date: 2020-01-18

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 64

Registration Number: NCT03416036

Locations: 🇺🇸
Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States
🇺🇸
Vaccine Testing Center, University of Vermont, Burlington, Vermont, United States

Evaluating the Safety and Pharmacokinetics of PC-1005 Administered Rectally to HIV-1 Seronegative Adults

Phase 1

Completed

Conditions: HIV Infections

Interventions: Drug: PC-1005 gel

First Posted Date: 2018-01-24

Last Posted Date: 2023-04-14

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 13

Registration Number: NCT03408899

Locations: 🇺🇸
University of Pittsburgh CRS, Pittsburgh, Pennsylvania, United States
🇺🇸
Alabama CRS, Birmingham, Alabama, United States

Evaluating the Safety and Immunogenicity of Env (A,B,C,A/E)/Gag (C) DNA and gp120 (A,B,C,A/E) Protein/GLA-SE HIV Vaccines, Given Individually or Co-administered, in Healthy, HIV-1-Uninfected Adults

Phase 1

Completed

Conditions: HIV Infections

Interventions: Biological: Placebo
Biological: env (A,B,C,A/E)/gag (C) DNA Vaccine
Biological: gp120 (A,B,C,A/E) Protein Vaccine
Biological: GLA-SE adjuvant

First Posted Date: 2018-01-24

Last Posted Date: 2022-04-25

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 60

Registration Number: NCT03409276

Locations: 🇺🇸
Penn Prevention CRS, Philadelphia, Pennsylvania, United States
🇺🇸
Case Clinical Research Site, Cleveland, Ohio, United States
🇺🇸
The Hope Clinic of the Emory Vaccine Center CRS, Decatur, Georgia, United States

and more 3 locations

A Study to Evaluate the Safety, Tolerability and Plasma PK of a Single Oral Dose of Zoliflodacin in Healthy Male and Female Volunteers

Phase 1

Completed

Conditions: Gonorrhoea

Interventions: Drug: AZD0914

First Posted Date: 2018-01-19

Last Posted Date: 2019-03-18

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 8

Registration Number: NCT03404167

Locations: 🇺🇸
Quintiles Phase I Services - Overland Park, Overland Park, Kansas, United States

NNITS-Nitazoxanide for Norovirus in Transplant Patients Study

Phase 2

Completed

Conditions: Gastroenteritis Norovirus

Interventions: Other: Placebo
Drug: Nitazoxanide

First Posted Date: 2018-01-10

Last Posted Date: 2023-10-11

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 31

Registration Number: NCT03395405

Locations: 🇺🇸
Northwestern University - Comprehensive Transplant Center, Chicago, Illinois, United States
🇺🇸
Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore, Maryland, United States
🇺🇸
University of Pittsburgh - Medicine - Infectious Diseases, Pittsburgh, Pennsylvania, United States

and more 9 locations

The Mechanistic Biology of Primary Immunodeficiency Disorders

Recruiting

Conditions: Primary Immunodeficiency Disorders

First Posted Date: 2018-01-09

Last Posted Date: 2024-12-09

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 2500

Registration Number: NCT03394053

Locations: 🇺🇸
Children's National Health System (CNHS), Washington, District of Columbia, United States
🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Pharmacokinetic Study of Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults

Phase 1

Completed

Conditions: HIV Infections

Interventions: Drug: Dapivirine gel

First Posted Date: 2018-01-08

Last Posted Date: 2021-10-25

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 16

Registration Number: NCT03393468

Locations: 🇺🇸
University of Pittsburgh CRS, Pittsburgh, Pennsylvania, United States

Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis

Phase 4

Terminated

Conditions: Atopic Dermatitis (AD)

Interventions: Drug: Dupilumab
Drug: Placebo

First Posted Date: 2018-01-04

Last Posted Date: 2021-10-04

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 72

Registration Number: NCT03389893

Locations: 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
University of Rochester Medical Center, Rochester, New York, United States
🇺🇸
Stanford University, Stanford, California, United States

and more 6 locations

Challenge Infection of Healthy Adult Volunteers With RSV A2

Phase 1

Completed

Conditions: Upper Respiratory Tract Infections

Interventions: Biological: 10^7 PFU of RSV A2
Biological: 10^6.3 PFU of RSV A2

First Posted Date: 2018-01-03

Last Posted Date: 2020-12-03

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 19

Registration Number: NCT03388645

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

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