NATIONAL INSTITUTES OF HEALTH

🇺🇸United States

Country: 🇺🇸United States

Ownership: Subsidiary, Private

Established: 1948-01-01

Employees: 1K

Market Cap: -

Website: http://www.nidcr.nih.gov

Clinical Trials

Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders

Phase 1

Completed

Conditions: Adult Acute Megakaryoblastic Leukemia
Adult Acute Monoblastic Leukemia
Adult Acute Monocytic Leukemia
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With Maturation
Adult Acute Myeloid Leukemia With Minimal Differentiation
Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1
Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A
Adult Acute Myeloid Leukemia Without Maturation

Interventions: Drug: Carboplatin
Other: Laboratory Biomarker Analysis
Drug: Topotecan Hydrochloride
Drug: Veliparib

First Posted Date: 2008-01-09

Last Posted Date: 2025-04-02

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 12

Registration Number: NCT00588991

Locations: 🇺🇸
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase 3

Active, not recruiting

Conditions: Recurrent Laryngeal Squamous Cell Carcinoma
Recurrent Oral Cavity Verrucous Carcinoma
Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7
Recurrent Salivary Gland Carcinoma
Stage IV Major Salivary Gland Cancer AJCC v7
Stage IVA Laryngeal Verrucous Carcinoma AJCC v7
Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7
Neck Squamous Cell Carcinoma of Unknown Primary

Interventions: Drug: Cisplatin
Biological: Bevacizumab
Drug: Carboplatin
Drug: Docetaxel
Drug: Fluorouracil
Other: Laboratory Biomarker Analysis

First Posted Date: 2008-01-09

Last Posted Date: 2025-05-11

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 403

Registration Number: NCT00588770

Locations: 🇺🇸
Providence Hospital, Mobile, Alabama, United States
🇺🇸
University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States
🇺🇸
Fairbanks Memorial Hospital, Fairbanks, Alaska, United States

and more 778 locations

Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage

Phase 2

Completed

Conditions: Thymic Carcinoma
Thymoma

Interventions: Drug: Belinostat (PDX101)

First Posted Date: 2008-01-09

Last Posted Date: 2015-09-30

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 41

Registration Number: NCT00589290

Locations: 🇺🇸
Indiana University Cancer Center, Indianapolis, Indiana, United States
🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

African American Study of Kidney Disease and Hypertension ABPM Pilot Study

Phase 2

Completed

Conditions: Hypertensive Renal Disease

Interventions: Behavioral: USUAL - take your BP Meds as you usually do
Drug: ADD On Dosing
Behavioral: HS DOSING

First Posted Date: 2007-12-28

Last Posted Date: 2012-04-16

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 180

Registration Number: NCT00582777

Locations: 🇺🇸
University of Alabama, Birmingham, Alabama, United States
🇺🇸
University of Southern California, Los Angeles, California, United States
🇺🇸
Charles Drew Medical College, Los Angeles, California, United States

and more 13 locations

Gemcitabine Hydrochloride and Tanespimycin in Treating Patients With Stage IV Pancreatic Cancer

Phase 2

Completed

Conditions: Adenocarcinoma of the Pancreas
Recurrent Pancreatic Cancer
Stage IV Pancreatic Cancer

Interventions: Drug: gemcitabine hydrochloride
Drug: tanespimycin

First Posted Date: 2007-12-20

Last Posted Date: 2014-07-25

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 21

Registration Number: NCT00577889

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery

Phase 1

Completed

Conditions: Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
Unresectable Solid Neoplasm
Triple-Negative Breast Carcinoma

Interventions: Drug: Irinotecan Hydrochloride
Other: Laboratory Biomarker Analysis
Other: Pharmacological Study
Drug: Veliparib

First Posted Date: 2007-12-19

Last Posted Date: 2025-04-15

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 73

Registration Number: NCT00576654

Locations: 🇺🇸
Yale University, New Haven, Connecticut, United States
🇺🇸
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States
🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 2 locations

A Cafeteria Based Study of Weight Gain Prevention

Not Applicable

Completed

Conditions: Obesity
Overweight

Interventions: Behavioral: control
Behavioral: REDE

First Posted Date: 2007-12-14

Last Posted Date: 2010-02-25

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 106

Registration Number: NCT00573482

Locations: 🇺🇸
Local Hospitals, Philadelphia, Pennsylvania, United States

Phase II Study of Fluorine-18 3'-Deoxy-3'-Fluorothymidine (F-18-FLT) in Invasive Breast Cancer

Phase 2

Completed

Conditions: Stage IIIB Breast Cancer
Stage IIIC Breast Cancer
Stage IIB Breast Cancer
Stage IIIA Breast Cancer

Interventions: Procedure: CT
Drug: 18F-FLT
Procedure: PET

First Posted Date: 2007-12-13

Last Posted Date: 2016-12-30

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 90

Registration Number: NCT00572728

Locations: 🇺🇸
Scottsdale Medical Imaging Limited, Scottsdale, Arizona, United States
🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
🇺🇸
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

and more 24 locations

Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia

Phase 1

Terminated

Conditions: Oral Leukoplakia

Interventions: Drug: aminolevulinic acid hydrochloride
Drug: photodynamic therapy
Other: laboratory biomarker analysis

First Posted Date: 2007-12-12

Last Posted Date: 2014-10-09

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 15

Registration Number: NCT00571558

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸
Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, United States
🇺🇸
University of Chicago, Chicago, Illinois, United States

and more 1 locations

Computer Based Intervention for Type 2 Diabetes in Youth

Not Applicable

Completed

Conditions: Type 2 Diabetes

Interventions: Behavioral: Video Games
Behavioral: Web and DVD knowledge

First Posted Date: 2007-12-11

Last Posted Date: 2017-09-27

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 153

Registration Number: NCT00570466

Locations: 🇺🇸
Baylor College of Medicine, Houston, Texas, United States

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NATIONAL INSTITUTES OF HEALTH

Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage

African American Study of Kidney Disease and Hypertension ABPM Pilot Study

Gemcitabine Hydrochloride and Tanespimycin in Treating Patients With Stage IV Pancreatic Cancer

Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery

A Cafeteria Based Study of Weight Gain Prevention

Phase II Study of Fluorine-18 3'-Deoxy-3'-Fluorothymidine (F-18-FLT) in Invasive Breast Cancer

Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia

Computer Based Intervention for Type 2 Diabetes in Youth