H. Lee Moffitt Cancer Center and Research Institute, Inc.

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Genomically Guided Radiation Dose Personalization in Locally Advanced NSCLC

Early Phase 1

Active, not recruiting

Conditions: Nonsmall Cell Lung Cancer, Stage II
Nonsmall Cell Lung Cancer Stage III
Nonsmall Cell Lung Cancer
Unresectable Non-Small Cell Lung Carcinoma

Interventions: Radiation: Genomically Guided Radiation Therapy (RT)

First Posted Date: 2023-05-24

Last Posted Date: 2025-03-14

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 3

Registration Number: NCT05873439

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Outreach Core Activities

Recruiting

Conditions: Cancer Education
Spanish Language Cancer Education

Interventions: Behavioral: Community Engagement (CE) Training Program for U54 Partnership Investigators
Behavioral: Cancer CientoUno (101) program
Behavioral: Community-based Training Program (CBTP) for Community Leaders and Stakeholders.
Behavioral: Integrate Cancer 101 into the Stakeholders Programs
Behavioral: Lunch and Learn Updated Recommendations Series.
Behavioral: Community Advisory Panels (CAP)
Behavioral: Research Corner
Behavioral: Community Engagement (CE) Training Program for Lay Community Members

First Posted Date: 2023-04-27

Last Posted Date: 2025-02-13

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 1200

Registration Number: NCT05832177

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States
🇵🇷
Ponce Health Sciences University, Ponce, Puerto Rico

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Phase 1

Recruiting

Conditions: Triple Negative Breast Cancer
HER2-positive Breast Cancer
Leptomeningeal Disease

Interventions: Biological: Dendritic Cell Vaccine

First Posted Date: 2023-04-12

Last Posted Date: 2025-03-13

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 18

Registration Number: NCT05809752

Locations: 🇺🇸
Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States
🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States
🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors

Not Applicable

Recruiting

Conditions: Larynx Cancer
Oropharynx Cancer
Oral Cavity Cancer
Hypopharynx Cancer

Interventions: Behavioral: ENHANCE Intervention - Nutrition Only
Behavioral: ENHANCE Intervention - Exercise and Nutrition

First Posted Date: 2023-04-05

Last Posted Date: 2025-05-07

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 40

Registration Number: NCT05798780

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Intravesical Adoptive Cell Therapy w/ TIL for BCG Exposed High Grade NMIBC

Phase 1

Recruiting

Conditions: Non-Invasive Bladder Urothelial Carcinoma
Urothelial Carcinoma

Interventions: Biological: Adoptive Cell Therapy with Tumor-infiltrating Lymphocytes (TIL)

First Posted Date: 2023-03-14

Last Posted Date: 2025-05-06

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 12

Registration Number: NCT05768347

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

Not Applicable

Active, not recruiting

Conditions: Leukemia
Myeloma
Lymphoma

Interventions: Behavioral: Resistance Training
Behavioral: Aerobic Exercise
Behavioral: Optional Aerobic Exercise Procedure
Radiation: Optional In-Person Exercise Sessions

First Posted Date: 2023-03-10

Last Posted Date: 2025-05-07

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 20

Registration Number: NCT05763563

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

Phase 2

Recruiting

Conditions: Diffuse Large B Cell Lymphoma

Interventions: Drug: Itacitinib
Biological: Chimeric antigen receptor (CAR) T-cell therapy

First Posted Date: 2023-03-07

Last Posted Date: 2025-03-13

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 27

Registration Number: NCT05757219

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer

Phase 2

Recruiting

Conditions: Metastatic Prostate Cancer
Prostate Cancer

Interventions: Drug: Abiraterone
Drug: Enzalutamide
Drug: Apalutamide
Drug: Sipuleucel-T

First Posted Date: 2023-03-02

Last Posted Date: 2025-05-15

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 26

Registration Number: NCT05751941

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS

Not Applicable

Recruiting

Conditions: Smoking Cessation
HIV

Interventions: Behavioral: Smartphone-delivered Automated Messaging
Drug: Nicotine patch
Behavioral: Brief Advice to Quit and Smoking Cessation Self Help Materials
Behavioral: Diet Assessment

First Posted Date: 2023-02-27

Last Posted Date: 2025-03-17

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 800

Registration Number: NCT05746442

Locations: 🇰🇭
National AIDS Authority, Phnom Penh, Cambodia
🇰🇭
National Institute of Public Health, Phnom Penh, Cambodia
🇰🇭
National Center for HIV/AIDS, Dermatology and STD, Phnom Penh, Cambodia

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

Phase 2

Recruiting

Conditions: Myelodysplastic Syndromes
Myeloproliferative Neoplasm
Anemia

Interventions: Drug: Luspatercept

First Posted Date: 2023-02-17

Last Posted Date: 2025-05-07

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 70

Registration Number: NCT05732961

Locations: 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States

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