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Lyra Therapeutics

Lyra Therapeutics logo
🇺🇸United States
Ownership
Public
Established
2005-01-01
Employees
145
Market Cap
$21.6M
Website
http://www.lyratherapeutics.com

Clinical Trials

5

Active:0
Completed:5

Trial Phases

3 Phases

Phase 1:1
Phase 2:2
Phase 3:2

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (5 trials with phase data)• Click on a phase to view related trials

Phase 2
2 (40.0%)
Phase 3
2 (40.0%)
Phase 1
1 (20.0%)

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)

Phase 3
Completed
Conditions
Chronic Sinusitis
Chronic Rhinosinusitis (Diagnosis)
Interventions
Drug: Sham procedure control
Other: Background therapy
First Posted Date
2022-03-25
Last Posted Date
2025-05-02
Lead Sponsor
Lyra Therapeutics
Target Recruit Count
182
Registration Number
NCT05295459
Locations
🇺🇸

Novak Clinical Trials, Tucson, Arizona, United States

🇺🇸

Keck School of Medicine at USC Medical Center, Arcadia, California, United States

🇺🇸

Sensa Health Clinical Research, Los Angeles, California, United States

and more 51 locations

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults

Phase 3
Completed
Conditions
Chronic Sinusitis
Chronic Rhinosinusitis (Diagnosis)
Interventions
Drug: Sham procedure control
Other: Background Therapy
First Posted Date
2022-02-02
Last Posted Date
2025-05-02
Lead Sponsor
Lyra Therapeutics
Target Recruit Count
196
Registration Number
NCT05219968
Locations
🇪🇸

Lyra Investigational Site, Santander, Spain

LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)

Phase 2
Completed
Conditions
Chronic Sinusitis
Chronic Rhinosinusitis (Diagnosis)
Interventions
Drug: LYR-220 Design 1 (Part 1 only)
Drug: LYR-220 Design 2 (Part 1 and Part 2)
Drug: Bilateral sham procedure control (Part 2)
First Posted Date
2021-09-05
Last Posted Date
2024-12-17
Lead Sponsor
Lyra Therapeutics
Target Recruit Count
48
Registration Number
NCT05035654
Locations
🇦🇺

Lyra Investigational Site, Melbourne, Australia

LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study)

Phase 2
Completed
Conditions
Chronic Sinusitis
Chronic Rhinosinusitis (Diagnosis)
Interventions
Other: Sham comparator
First Posted Date
2019-08-01
Last Posted Date
2023-07-25
Lead Sponsor
Lyra Therapeutics
Target Recruit Count
71
Registration Number
NCT04041609
Locations
🇦🇺

Royal Brisbane and Woman's Hospital, Brisbane, Australia

🇦🇺

Monash Health, Clayton, Australia

🇦🇺

The ENT Centre, Hornsby, Australia

and more 19 locations

480 Biomedical Sinus Drug Depot

Phase 1
Completed
Conditions
Chronic Sinusitis
Interventions
Drug: 480 Mometasone Furoate Sinus Drug Depot
First Posted Date
2016-11-18
Last Posted Date
2021-08-25
Lead Sponsor
Lyra Therapeutics
Target Recruit Count
20
Registration Number
NCT02967731
Locations
🇦🇺

The Queen Elizabeth Hospital, Adelaide, Australia

🇦🇺

Royal Brisbane and Women's Hospital, Brisbane, Australia

🇦🇺

Monash Medical Center, Melbourne, Australia

and more 1 locations

News

Lyra Therapeutics Completes Enrollment in Phase 3 Trial of LYR-210 for Chronic Rhinosinusitis

Lyra Therapeutics has fully enrolled its pivotal Phase 3 ENLIGHTEN 2 trial evaluating LYR-210 for chronic rhinosinusitis (CRS) in adults without prior ethmoid sinus surgery.

Lyra Therapeutics' Phase 3 ENLIGHTEN 1 Trial for Chronic Rhinosinusitis Treatment Fails to Meet Primary Endpoint

Lyra Therapeutics announced that its Phase 3 ENLIGHTEN 1 trial evaluating LYR-210, a bioabsorbable sinonasal implant for chronic rhinosinusitis, failed to meet its primary endpoint of demonstrating statistically significant improvement in cardinal symptoms compared to sham control at 24 weeks.

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