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MURAL ONCOLOGY, INC.

🇺🇸United States
Ownership
-
Employees
-
Market Cap
$56M
Website

Clinical Trials

12

Active:8
Completed:3

Trial Phases

3 Phases

Phase 1:9
Phase 2:2
Phase 3:1

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (12 trials with phase data)• Click on a phase to view related trials

Phase 1
9 (75.0%)
Phase 2
2 (16.7%)
Phase 3
1 (8.3%)

Phase 3 Study of Nemvaleukin Alfa in Combination With Pembrolizumab in Patients With Platinum-Resistant Epithelial Ovarian Cancer (ARTISTRY-7)

Phase 3
Active, not recruiting
Conditions
Platinum-resistant Ovarian Cancer
Primary Peritoneal Cancer
Fallopian Tube Cancer
Interventions
Biological: Pembrolizumab
Biological: Nemvaleukin
Biological: Nemvaleukin and Pembrolizumab Combination
First Posted Date
2021-10-25
Last Posted Date
2024-06-28
Lead Sponsor
Mural Oncology, Inc
Target Recruit Count
456
Registration Number
NCT05092360
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

Alaska Women's Cancer Care, Anchorage, Alaska, United States

🇺🇸

Arizona Oncology, Tucson, Arizona, United States

and more 114 locations

Nemvaleukin Alfa Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Cutaneous or Mucosal Melanoma - ARTISTRY-6

Phase 2
Terminated
Conditions
Cutaneous Melanoma
Mucosal Melanoma
Interventions
Drug: Nemvaleukin Alfa Subcutaneous
Drug: Nemvaleukin Alfa Intravenous
Drug: Nemvaleukin Alfa Intravenous Less Frequent Dosing
First Posted Date
2021-04-02
Last Posted Date
2025-06-10
Lead Sponsor
Mural Oncology, Inc
Target Recruit Count
173
Registration Number
NCT04830124
Locations
🇺🇸

UC San Diego Moores Cancer Center, La Jolla, California, United States

🇺🇸

The Angeles Clinic and Research Institute, Los Angeles, California, United States

🇺🇸

Mayo Clinic, Jacksonville, Florida, United States

and more 38 locations

Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3)

Phase 1
Active, not recruiting
Conditions
Advanced Solid Tumor
First Posted Date
2020-10-19
Last Posted Date
2024-06-07
Lead Sponsor
Mural Oncology, Inc
Target Recruit Count
78
Registration Number
NCT04592653
Locations
🇺🇸

START Midwest, Grand Rapids, Michigan, United States

🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

🇺🇸

START Mountain, West Valley City, Utah, United States

and more 3 locations

A Study of ALKS 4230 (Nemvaleukin Alfa) With Pembrolizumab in Head and Neck Cancer

Phase 2
Completed
Conditions
Squamous Cell Carcinoma of Head and Neck
Interventions
First Posted Date
2019-10-30
Last Posted Date
2024-10-16
Lead Sponsor
Mural Oncology, Inc
Target Recruit Count
14
Registration Number
NCT04144517
Locations
🇺🇸

Mural Oncology Investigational Site, Austin, Texas, United States

A Dose Escalation and Cohort Expansion Study of Subcutaneously-Administered Cytokine ALKS 4230 (Nemvaleukin Alfa) as a Single Agent and in Combination With Anti-PD-1 Antibody (Pembrolizumab) in Subjects With Select Advanced or Metastatic Solid Tumors (ARTISTRY-2)

Phase 1
Completed
Conditions
Advanced Solid Tumors
First Posted Date
2019-03-04
Last Posted Date
2024-03-05
Lead Sponsor
Mural Oncology, Inc
Target Recruit Count
116
Registration Number
NCT03861793
Locations
🇨🇳

Mural Oncology Investigational Site, Taipei, Taiwan

🇨🇦

Mural Oncology Investigational Sites, Montréal, Quebec, Canada

🇰🇷

National Cancer Center, Goyang, Korea, Republic of

and more 7 locations
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News

Mural Oncology Cuts 90% of Workforce Following Failed Cancer Immunotherapy Trials

Mural Oncology is discontinuing all clinical development of nemvaleukin alfa after the immunotherapy failed to meet target goals in melanoma and ovarian cancer trials.

Mural Oncology Gears Up for Key Data Readouts of Nemvaleukin in Ovarian Cancer and Melanoma in 2025

Mural Oncology's ARTISTRY-7 trial evaluating nemvaleukin with pembrolizumab in platinum-resistant ovarian cancer has reached 75% of overall survival events.

Nemvaleukin Shows Promising Antitumor Activity in Advanced Solid Tumors

Nemvaleukin, an engineered IL-2 fusion protein, demonstrates tolerability and antitumor activity in the ARTISTRY-1 phase 1/2 trial, both as monotherapy and in combination with pembrolizumab.

Mural Oncology's Nemvaleukin Trials Progressing, Data Readouts Anticipated in 2025

Mural Oncology remains on track with late-stage trials for nemvaleukin alfa, expecting data readouts for platinum-resistant ovarian cancer in late Q1/early Q2 2025.

Mural Oncology Highlights Nemvaleukin Progress and IL-18 Program at Investor Day

Mural Oncology's ARTISTRY-7 trial, evaluating nemvaleukin plus pembrolizumab in platinum-resistant ovarian cancer, anticipates interim data in early Q2 2025.

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