Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome
Phase 4
Completed
- Conditions
- PsoriasisMetabolic Syndrome
- Interventions
- Behavioral: Life-style intervention
- First Posted Date
- 2018-02-22
- Last Posted Date
- 2023-05-22
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 781
- Registration Number
- NCT03440736
- Locations
- 🇩🇪
Novartis Investigative Site, Wuppertal, Germany
Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus Fulvestrant
Phase 3
Completed
- Conditions
- Breast Cancer
- Interventions
- First Posted Date
- 2018-02-20
- Last Posted Date
- 2024-08-01
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 287
- Registration Number
- NCT03439046
- Locations
- 🇮🇹
Novartis Investigative Site, Napoli, Italy
Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Phase 2
Completed
- Conditions
- Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis
- Interventions
- Combination Product: Standard of Care
- First Posted Date
- 2018-02-20
- Last Posted Date
- 2024-06-12
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 16
- Registration Number
- NCT03439839
- Locations
- 🇮🇹
Novartis Investigative Site, Napoli, Italy
Study to Investigate the Efficacy and Safety of QGE031 in Adolescent Patients With Chronic Spontaneous Urticaria (CSU)
- First Posted Date
- 2018-02-19
- Last Posted Date
- 2022-04-29
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 49
- Registration Number
- NCT03437278
- Locations
- 🇹🇷
Novartis Investigative Site, Aydin, Turkey
VAY736 in Combination With Ibrutinib in Patients With CLL on Ibrutinib
Phase 1
Terminated
- Conditions
- Chronic Lymphocytic Leukemia (CLL)
- Interventions
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2025-05-16
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 39
- Registration Number
- NCT03400176
- Locations
- 🇺🇸
David Geffen School of Medicine at UCLA, Los Angeles, California, United States
🇺🇸Ohio ST Compr Cancer Ctr James Hosp, Columbus, Ohio, United States
🇺🇸SCRI Oncology Partners, Nashville, Tennessee, United States
Efficacy and Safety of MAA868 in Patients With Atrial Fibrillation
- First Posted Date
- 2018-01-12
- Last Posted Date
- 2020-10-08
- Lead Sponsor
- Novartis Pharmaceuticals
- Registration Number
- NCT03398434
Prevention of Thromboembolic Events in Total Knee Replacement Patients
- First Posted Date
- 2018-01-08
- Last Posted Date
- 2020-10-08
- Lead Sponsor
- Novartis Pharmaceuticals
- Registration Number
- NCT03393481
Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsartan) in Heart Failure
- First Posted Date
- 2017-12-29
- Last Posted Date
- 2019-12-13
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 402
- Registration Number
- NCT03387163
- Locations
- 🇺🇸
Novartis Investigative Site, New York, New York, United States
Study of Safety and Efficacy of Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With nAMD
Phase 3
Completed
- Conditions
- Neovascular Age-related Macular Degeneration
- Interventions
- First Posted Date
- 2017-12-29
- Last Posted Date
- 2021-01-05
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 151
- Registration Number
- NCT03386474
- Locations
- 🇵🇷
Novartis Investigative Site, San Juan, Puerto Rico
Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Maintenance Monotherapy in Patients With Newly-diagnosed FMS-like Tyrosine 3 (FLT3) Kinase Receptor-mutated Acute Myeloid Leukemia.
- First Posted Date
- 2017-12-20
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 301
- Registration Number
- NCT03379727
- Locations
- 🇸🇪
Novartis Investigative Site, Uppsala, Sweden