MASSACHUSETTS GENERAL HOSPITAL

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Established: 1811-01-01

Employees: -

Market Cap: -

Website: http://www.massgeneral.org/international

Clinical Trials

The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Recruiting

Conditions: Recurrent Respiratory Papillomatosis
Pulmonary Neoplasm

First Posted Date: 2024-05-14

Last Posted Date: 2024-05-17

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 100

Registration Number: NCT06412172

Locations: 🇺🇸
Yale School of Medicine, New Haven, Connecticut, United States

EVOC - EVs in Obesity and Cardiometabolic Disease

Active, not recruiting

Conditions: Cardiovascular Diseases

First Posted Date: 2024-05-10

Last Posted Date: 2024-06-05

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 80

Registration Number: NCT06408961

Locations: 🇺🇸
Massachusetts General Hospita;, Boston, Massachusetts, United States

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

Phase 2

Not yet recruiting

Conditions: Drug Allergy
Cephalosporin Allergy
Drug Hypersensitivity
Antibiotic Allergy
Beta Lactam Adverse Reaction
Drug-Induced Anaphylaxis
Cephalosporin Reaction

Interventions: Drug: Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
Drug: Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge
Drug: Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge
Drug: Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge
Drug: Amoxicillin double-blind placebo-controlled drug challenge

First Posted Date: 2024-05-09

Last Posted Date: 2024-11-20

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 300

Registration Number: NCT06406114

Locations: 🇺🇸
University of California, San Francisco, San Francisco, California, United States
🇺🇸
Mayo Clinic Arizona, Scottsdale, Arizona, United States
🇺🇸
Rochester General Hospital, Rochester, New York, United States

and more 2 locations

12-Step Facilitation/MET/CBT (InTEGRA) vs. MET/CBT for Youth With Alcohol and Other Drug Use Disorder

Not Applicable

Not yet recruiting

Conditions: Cannabis Use Disorder
Alcohol Use Disorder

Interventions: Behavioral: MET/CBT
Behavioral: InTEGRA

First Posted Date: 2024-05-02

Last Posted Date: 2024-05-07

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 294

Registration Number: NCT06395467

Locations: 🇺🇸
UConn Health, Farmington, Connecticut, United States
🇺🇸
MGH Department of Psychiatry, Boston, Massachusetts, United States

Pilot Randomized Clinical Trial of Change My Story

Not Applicable

Not yet recruiting

Conditions: Hiv
Psychological Distress
Depression

Interventions: Behavioral: Problem Solving Therapy
Other: Change My Story

First Posted Date: 2024-04-29

Last Posted Date: 2024-04-29

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 80

Registration Number: NCT06389565

The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

Not Applicable

Not yet recruiting

Conditions: Schizophrenia

Interventions: Other: Closed loop auditory stimulation during sleep

First Posted Date: 2024-04-26

Last Posted Date: 2024-12-13

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 60

Registration Number: NCT06386588

Locations: 🇺🇸
Massachusetts General Hospital, Charlestown, Massachusetts, United States

PET/MRI for Evaluation of Endometriosis

Not yet recruiting

Conditions: Endometriosis
Endometrioma

Interventions: Drug: Radiotracer Injection
Diagnostic Test: Imaging
Other: Rectal Ultrasound Gel Injection

First Posted Date: 2024-04-22

Last Posted Date: 2024-04-22

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 60

Registration Number: NCT06377553

Locations: 🇺🇸
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

Not Applicable

Recruiting

Conditions: Delayed Neurocognitive Recovery
Insomnia
Postoperative Delirium
Postoperative Neurocognitive Disorder

Interventions: Behavioral: Sleep Health Education
Behavioral: digital Cognitive Behavioral Therapy for Insomnia (dCBT-I)

First Posted Date: 2024-04-19

Last Posted Date: 2024-11-06

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 50

Registration Number: NCT06375265

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Study to Determine the Clinical Significance of Intravascular OCT-NIRAF

Not Applicable

Conditions: Cardiovascular Diseases
Coronary Artery Disease

Interventions: Device: OCT-NIRAF

First Posted Date: 2024-04-18

Last Posted Date: 2024-11-18

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 40

Registration Number: NCT06374498

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Single Participant Study of an Experimental ASO Treatment for TUBB4A-related Leukodystrophy

Phase 1

Not yet recruiting

Conditions: Genetic Disease

Interventions: Drug: Antisense oligonucleotide treatment (ASO)

First Posted Date: 2024-04-17

Last Posted Date: 2024-04-18

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 1

Registration Number: NCT06369974

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