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Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated logo
🇺🇸United States
Ownership
Public
Established
1989-01-01
Employees
5.4K
Market Cap
$123.9B
Website
http://www.vrtx.com

Clinical Trials

639

Active:400
Completed:178

Trial Phases

5 Phases

Phase 1:397
Phase 2:65
Phase 3:85
+2 more phases

Drug Approvals

4

FDA:4

Drug Approvals

Trikafta

Approval Date
Oct 16, 2023
FDA

Kalydeco

Approval Date
Oct 16, 2023
FDA

SYMDEKO

Approval Date
Oct 16, 2023
FDA

ORKAMBI

Approval Date
Aug 10, 2023
FDA

Clinical Trials

Distribution across different clinical trial phases (558 trials with phase data)• Click on a phase to view related trials

Phase 1
397 (71.1%)
Phase 3
85 (15.2%)
Phase 2
65 (11.6%)
Phase 4
5 (0.9%)
phase_1_2
3 (0.5%)
Not Applicable
2 (0.4%)
phase_2_3
1 (0.2%)

Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants

Not Applicable
Not yet recruiting
Conditions
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions
Drug: LNG/EE
Drug: NGM/EE
Drug: NET/EE
Drug: DRSP/EE
First Posted Date
2025-07-20
Last Posted Date
2025-07-20
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
148
Registration Number
NCT07074327

A Phase 1 Study Evaluating Safety, Tolerability, and Pharmacokinetics of VX-407 in Healthy Participants

Phase 1
Recruiting
Conditions
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions
Drug: Placebo
First Posted Date
2025-06-15
Last Posted Date
2025-07-15
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
24
Registration Number
NCT07022119
Locations
🇺🇸

ICON Lenexa, Lenexa, Kansas, United States

A Study to Evaluate the Relative Bioavailability of Povetacicept Formulations and Bioequivalence of Povetacicept Presentations

Phase 1
Recruiting
Conditions
Healthy Volunteers
Interventions
First Posted Date
2025-06-08
Last Posted Date
2025-07-17
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
136
Registration Number
NCT07010406
Locations
🇺🇸

Celerion - Tempe, Tempe, Arizona, United States

🇺🇸

Celerion - Lincoln, Lincoln, Nebraska, United States

A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic Dystrophy Type I

Phase 2
Conditions
Myotonic Dystrophy Type 1 (DM1)
Interventions
First Posted Date
2025-04-14
Last Posted Date
2025-07-08
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
36
Registration Number
NCT06926621
Locations
🇬🇧

Leonard Wolfson Experimental Neurology Centre CRF, London, United Kingdom

🇦🇺

Wesley Research Institute, Auchenflower, Australia

🇦🇺

Neuroscience Clinical Trials Unit, Alfred Brain, Melbourne, Australia

and more 2 locations

A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries

Phase 4
Recruiting
Conditions
Acute Pain
Interventions
First Posted Date
2025-03-21
Last Posted Date
2025-04-24
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
100
Registration Number
NCT06887972
Locations
🇺🇸

Atlanta Center for Medical Research, Atlanta, Georgia, United States

🇺🇸

HD Research LLC | First Surgical Hospital, Bellaire, Texas, United States

🇺🇸

Memorial Hermann Village, Houston, Texas, United States

and more 1 locations
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