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Praxis Precision Medicines

Praxis Precision Medicines logo
🇺🇸United States
Ownership
Public
Established
2015-09-22
Employees
82
Market Cap
$950.3M
Website
http://www.praxismedicines.com
Introduction

Praxis Precision Medicines, Inc. is a clinical-stage biopharmaceutical company, which engages in the genetic epilepsies into the development of therapies for central nervous system, or CNS, disorders characterized by neuronal excitation-inhibition imbalance. It focuses on two proprietary platforms: Cerebrum and Solidus. The Cerebrum platform utilizes a deep understanding of neuronal excitability and neuronal networks and applies a series of computational and experimental tools to develop orally available precision therapies. The Solidus platform consists of antisense oligonucleotide, or ASO. It is a targeted precision medicine discovery and development engine anchored on a proprietary, computational methodology. The company was founded by Kiran Reddy, David Goldstein, and Steven Petrou on September 22, 2015 and is headquartered in Boston, MA.

An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures

Phase 2
Recruiting
Conditions
Focal Onset Seizure
Primary Generalized Epilepsy
Interventions
Drug: 30mg PRAX-628
First Posted Date
2025-04-03
Last Posted Date
2025-04-03
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
50
Registration Number
NCT06908356
Locations
🇪🇸

Praxis Research Site, Madrid, Spain

A Clinical Trial to Evaluate the Relative Bioavailability of PRAX-628

Phase 1
Not yet recruiting
Conditions
Healthy
Interventions
First Posted Date
2025-02-21
Last Posted Date
2025-02-21
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
16
Registration Number
NCT06840925
Locations
🇦🇺

Nucleus Network Melbourne, Melbourne, Victoria, Australia

Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)

Phase 3
Recruiting
Conditions
Essential Tremor
Interventions
Drug: 60 mg ulixacaltamide
Drug: Placebo
First Posted Date
2023-10-17
Last Posted Date
2024-04-05
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
600
Registration Number
NCT06087276
Locations
🇺🇸

United BioSource LLC, Morgantown, West Virginia, United States

A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)

Phase 2
Recruiting
Conditions
SCN2A Encephalopathy
SCN8A Encephalopathy
Interventions
First Posted Date
2023-04-19
Last Posted Date
2025-01-28
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
100
Registration Number
NCT05818553
Locations
🇪🇸

Praxis Research Site, Madrid, Spain

A Clinical Trial of PRAX-222 in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy

Phase 1
Recruiting
Conditions
SCN2A-DEE
Epilepsy
Interventions
Procedure: Placebo
Drug: PRAX-222 - Fixed Doses
Drug: PRAX-222 - Initial Dose
Drug: PRAX-222 - Initial Ascending Doses
Drug: PRAX-222 - Optional Ascending Doses
First Posted Date
2023-02-21
Last Posted Date
2024-10-04
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
60
Registration Number
NCT05737784
Locations
🇺🇸

Le Bonheur Childrens Hospital, Memphis, Tennessee, United States

🇧🇷

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

A Prospective, Remote Observational Study in Pediatric Participants With Early-Onset SCN2A-Developmental and Epileptic Encephalopathy

Completed
Conditions
SCN2A-DEE
Epilepsy
First Posted Date
2022-06-07
Last Posted Date
2024-01-10
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
5
Registration Number
NCT05407727
Locations
🇺🇸

Praxis Research Site, Atlanta, Georgia, United States

A Clinical Trial of PRAX-114 in Participants With Essential Tremor

Phase 2
Withdrawn
Conditions
Essential Tremor
Interventions
Drug: 10 mg PRAX-114, 20 mg PRAX-114, and Placebo
Drug: 10 mg PRAX-114 or 20 mg PRAX-114
First Posted Date
2022-05-24
Last Posted Date
2022-11-30
Lead Sponsor
Praxis Precision Medicines
Registration Number
NCT05387642
Locations
🇺🇸

Praxis Research Site, Kirkland, Washington, United States

A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder

Phase 2
Terminated
Conditions
Post-traumatic Stress Disorder
Stress Disorder
Mental Disorder
Post Traumatic Stress Disorder
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Interventions
Drug: 60 mg PRAX-114 or 40 mg PRAX-114
Drug: Placebo
Drug: 40 mg PRAX-114
First Posted Date
2022-03-02
Last Posted Date
2022-12-01
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
11
Registration Number
NCT05260541
Locations
🇺🇸

Praxis Research Site, Everett, Washington, United States

A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor

Phase 2
Completed
Conditions
Essential Tremor
Interventions
Drug: 100 mg PRAX-944
Drug: 60 mg PRAX-944
Drug: Placebo
Drug: Flexibly dosed 20 mg to 100 mg PRAX-944
First Posted Date
2021-08-26
Last Posted Date
2024-03-13
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
133
Registration Number
NCT05021991
Locations
🇨🇦

Praxis Research Site, Montréal, Quebec, Canada

A Clinical Trial of PRAX-944 in Participants With Essential Tremor

Phase 2
Completed
Conditions
Essential Tremor
First Posted Date
2021-08-26
Last Posted Date
2024-03-01
Lead Sponsor
Praxis Precision Medicines
Target Recruit Count
24
Registration Number
NCT05021978
Locations
🇳🇿

Praxis Research Site, Christchurch, New Zealand

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