JOHN HOPE FRANKLIN CENTER

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private

Established: 1838-01-01

Employees: 5K

Market Cap: -

Website: http://www.duke.edu

Clinical Trials

Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study)

Phase 3

Completed

Conditions: Heart Failure

Interventions: Drug: Placebo
Drug: Sildenafil

First Posted Date: 2008-10-01

Last Posted Date: 2014-07-23

Lead Sponsor: Duke University

Target Recruit Count: 216

Registration Number: NCT00763867

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸
University of Utah Health Sciences Center, Murray, Utah, United States

and more 7 locations

Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders

Phase 1

Completed

Conditions: Immunodeficiencies
Congenital Marrow Failures
Inborn Errors of Metabolism
Non Malignant Disorders
Hemoglobinopathies
Sickle Cell
Thalassemia
Lysosomal Storage Disease

Interventions: Biological: Unrelated Umbilical Cord Blood Transplant
Drug: Reduced Intensity Conditioning

First Posted Date: 2008-09-01

Last Posted Date: 2014-08-13

Lead Sponsor: Duke University

Target Recruit Count: 22

Registration Number: NCT00744692

Locations: 🇺🇸
Duke University Medical Center Pediatric Blood and Marrow Transplant Program, Durham, North Carolina, United States

Effect on Bleeding When Using FloSeal Matrix™ in Subjects Undergoing Endoscopic Vein Harvest (EVH)

Phase 4

Terminated

Conditions: Bleeding

Interventions: Biological: FloSeal Matrix

First Posted Date: 2008-08-27

Last Posted Date: 2014-03-05

Lead Sponsor: Duke University

Target Recruit Count: 50

Registration Number: NCT00742313

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Does Echocardiographically Guided Ventriculo-Ventricular Optimization Yield a Sustained Improvement in Echocardiographic Parameters in Cardiac Resynchronization Therapy Patients? (DEVISE CRT)

Not Applicable

Completed

Conditions: Heart Failure
Cardiomyopathy

Interventions: Other: "Simultaneous Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343)
Other: "Sequential Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343)

First Posted Date: 2008-08-19

Last Posted Date: 2014-08-01

Lead Sponsor: Duke University

Target Recruit Count: 40

Registration Number: NCT00737490

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Metformin for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)

Phase 4

Terminated

Conditions: Fatty Liver

Interventions: Drug: Glucophage (Metformin)
Drug: Placebo

First Posted Date: 2008-08-15

Last Posted Date: 2024-01-26

Lead Sponsor: Duke University

Target Recruit Count: 11

Registration Number: NCT00736385

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)

Phase 2

Terminated

Conditions: Malignant Glioma
Glioblastoma Multiforme
Gliosarcoma

Interventions: Drug: Gliadel/Avastin/CPT-11

First Posted Date: 2008-08-15

Last Posted Date: 2013-02-11

Lead Sponsor: Duke University

Target Recruit Count: 18

Registration Number: NCT00735436

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Memory and Picture Viewing Study

Completed

Conditions: Brain Reactivity of Non-smokers Undergoing fMRI Scanning
Healthy

First Posted Date: 2008-08-15

Last Posted Date: 2013-02-07

Lead Sponsor: Duke University

Target Recruit Count: 116

Registration Number: NCT00736203

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

A Trial of Aprepitant For Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis

Not Applicable

Completed

Conditions: Pancreatitis

Interventions: Drug: aprepitant
Drug: Placebo

First Posted Date: 2008-08-15

Last Posted Date: 2015-06-22

Lead Sponsor: Duke University

Target Recruit Count: 73

Registration Number: NCT00736073

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

PARTNER Recruitment and Brief Intervention Pilot Study

Phase 1

Completed

Conditions: Alcohol Abuse

First Posted Date: 2008-08-15

Last Posted Date: 2010-08-23

Lead Sponsor: Duke University

Target Recruit Count: 300

Registration Number: NCT00735956

Locations: 🇺🇸
Duke University, Durham, North Carolina, United States

Coping Skills for Patients With Chronic Obstructive Pulmonary Disease (COPD) and Their Caregivers

Not Applicable

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Behavioral: Telephone-based Enhanced Coping Skills Training (CST)
Other: Usual Medical Care and COPD education and symptom monitoring (UMC)

First Posted Date: 2008-08-15

Last Posted Date: 2014-08-07

Lead Sponsor: Duke University

Target Recruit Count: 746

Registration Number: NCT00736268

Locations: 🇺🇸
Ohio State University, Columbus, Ohio, United States
🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

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