Clinical Trials
13
2 active
Approvals
0
Total approvals
Agencies
0
Regulatory bodies
Founded
1924
Completed
5
38.5%
Enrolling By Invitation
2
15.4%
Recruiting
4
30.8%
Terminated
1
7.7%
Unknown
1
7.7%
No approval data available
- Two studies following over 6,000 adults for 10 years found coronary artery calcium scores only modestly improved cardiovascular risk prediction when added to the PREVENT calculator. - In patients classified as borderline or intermediate risk by PREVENT, calcium scoring produced more meaningful reclassification of who would and would not have a heart attack or stroke. - Researchers cautioned that routine calcium scanning in low-risk people brings unnecessary radiation, testing and costs, while high-risk patients should start statins regardless of scan results. - A separate JACC analysis found some patients with a calcium score of zero still had events, indicating CAC should not be used to withhold statin therapy.
- Exercise provides cardiometabolic health benefits, including improved cholesterol, lower blood pressure, and reduced heart disease risk, independently of weight loss, according to an American Heart Association scientific statement. - A study of over 1,100 people found that higher physical activity levels after weight loss were strongly linked to maintaining that weight loss, even though exercise had little effect on initial weight loss. - Combining exercise with weight-loss drugs such as Saxenda may help people maintain weight loss better than using the drug alone. - Resistance training helps preserve muscle mass and resting energy expenditure, which may aid long-term weight maintenance and reduce age-related fragility.
- A new study finds nearly 1 in 3 U.S. adults with untreated high blood pressure would benefit from medication but are not receiving it, totaling roughly 9.7 million people. - Applying the 2025 AHA/ACC PREVENT tool, about 81 million Americans would be eligible for blood pressure medication, with nearly 23 million newly eligible under updated guidelines. - Treatment was associated with a 23% lower risk of all-cause death and a 50% lower risk of cardiovascular death, with adults with diabetes benefiting most. - Researchers estimate approximately 200,900 all-cause deaths and 162,600 cardiovascular deaths could be prevented over the next 10 years if all eligible untreated adults were treated.
- A 12-week randomized trial of 74 adults with overweight or obesity found three daily servings of full-fat dairy caused no meaningful changes in body weight, body composition, or cholesterol compared with a low-dairy diet. - Participants consuming full-fat dairy showed lower blood pressure and higher intake of calcium, protein, and vitamin D, with no evidence of increased insulin resistance or adverse blood lipid levels. - Researchers attribute the findings to the "dairy matrix hypothesis," which proposes that dairy's physical structure slows nutrient delivery and alters the effects of its saturated fat. - The results challenge long-standing low-fat dairy guidance, though experts caution the study did not directly compare full-fat versus low-fat dairy and may have been too short to detect longer-term effects.
- The MUTTON-HF trial showed that eight weeks of culturally tailored Navajo meals reduced all-cause hospitalizations or ER visits by 28% compared to usual care among 206 heart failure patients. - All-cause hospitalizations were cut by more than half (12.3% vs. 26.0%), and heart failure-specific hospitalizations dropped nearly 70% (3.8% vs. 13.0%). - Participants receiving tailored meals lost an average of 6.3 pounds more and experienced significant reductions in both systolic and diastolic blood pressure. - The study, published in JAMA Internal Medicine, is the first randomized clinical trial to evaluate an Indigenous Food is Medicine intervention for cardiovascular health.
- A second-year medical student in Nepal, Raghabendra Kumar Mahato, operates an international research network of nearly 1,000 members via WhatsApp that produces fast-churn conference abstracts and journal papers. - Retraction Watch's investigation revealed authorship is bartered for conference presentation and publication fees, with a known paper miller serving as an administrator in the network. - Research Square has withdrawn three preprints by Mahato citing concerns about paper mill involvement, and the Global Association of Indian Medical Students terminated his editorial board position. - The network has placed abstracts at major conferences including those of the American Heart Association and European Society for Medical Oncology, both now investigating the submissions.
- Three Dignity Health North State hospitals received multiple Get With The Guidelines awards from the American Heart Association for adherence to research-based cardiovascular and stroke care protocols. - Mercy Medical Center Redding earned three awards including STEMI Receiving Silver, NSTEMI Gold, and Stroke Gold Plus with Target: Stroke Honor Roll Elite Plus and Advanced Therapy recognition. - Heart disease and stroke remain the No. 1 and No. 5 causes of death in the United States, respectively, according to the American Heart Association 2025 Statistical Update. - The awards reflect data collected from January 2024 to December 2025, with Gold recognition signifying at least two consecutive years of compliance with evidence-based guidelines.
- Consuming up to 400 mg of caffeine per day—equivalent to 3 to 5 cups of caffeinated coffee—is generally safe for most adults and does not increase cardiovascular risk, according to a new AHA scientific statement. - Moderate caffeinated coffee intake was linked to lower risks of Type 2 diabetes, heart disease, stroke, heart failure, and some arrhythmias, though most evidence is observational and cannot prove causation. - High-dose caffeine from energy drinks and shots may cause cardiovascular harm, including elevated blood pressure and irregular heart rhythms, and should be avoided. - The statement emphasizes individualized caffeine tolerance, noting that genetics, metabolism, and health conditions influence how people respond to caffeine.
- The American College of Obstetricians & Gynecologists, Society for Women's Health Research, and Women First Research Coalition unveiled a national framework calling on Congress to invest $20 billion over 10 years to transform women's health research, care, and outcomes. - The strategy outlines five key priorities: research and innovation, regulatory coordination, data infrastructure, workforce development, and public awareness and education. - The framework has been endorsed by more than 40 leading health organizations, including the American Heart Association, Endocrine Society, and March of Dimes. - The initiative builds on the 1993 NIH Revitalization Act, addressing persistent gaps in women's health research, clinical care, and implementation that remain despite women comprising over half the U.S. population.
- Researchers found Porphyromonas gingivalis, a bacterium driving gum disease, accumulates in calcified aortic valves and may contribute to calcific aortic valve stenosis (CAVS). - Mouse studies revealed that repeated exposure to live P. gingivalis led to valve calcification and aortic stenosis symptoms, while preventive antibiotics reduced these effects. - Genetic deletion of the IL-1β inflammatory pathway significantly reduced valve calcification even in the presence of the bacterium, identifying a potential therapeutic target. - The findings, presented at the AHA's BCVS 2026 meeting, are preliminary and have not yet been confirmed in humans; a clinical study is now underway.
