Great Ormond Street Hospital for Children NHS Foundation Trust

🇬🇧United Kingdom

Country: 🇬🇧United Kingdom

Ownership: Private

Employees: -

Market Cap: -

Website: http://www.gosh.nhs.uk

Clinical Trials

Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases

Not Applicable

Completed

Conditions: Esophageal Atresia With Tracheo-esophageal Fistula
Congenital Diaphragmatic Hernia

Interventions: Procedure: Hypercapnia during thoracoscopy
Procedure: Open surgery

First Posted Date: 2011-11-08

Last Posted Date: 2022-03-02

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 20

Registration Number: NCT01467245

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

NEMO1:NEonatal Seizure Using Medication Off-patent

Phase 1

Completed

Conditions: Neonatal Seizures

Interventions: Drug: Bumetanide

First Posted Date: 2011-09-14

Last Posted Date: 2015-09-14

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 14

Registration Number: NCT01434225

Locations: 🇮🇪
Cork University Maternity Hospital, Cork, Ireland
🇳🇱
Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
🇳🇱
University Medical Centre Utrecht, Utrecht, Netherlands

and more 4 locations

Lentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)

Phase 1

Withdrawn

Conditions: Granulomatous Disease, Chronic, X-linked, Variant

Interventions: Genetic: pCCLchimGp91s lentiviral vector transduced CD34+ cells infusion

First Posted Date: 2011-06-27

Last Posted Date: 2012-06-04

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Registration Number: NCT01381003

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Phase 1

Completed

Conditions: Adenosine Deaminase Deficiency
Severe Combined Immunodeficiencies (SCID)

Interventions: Other: Haematopoietic Stem Cell Transplantation (HSCT)
Genetic: Infusion of autologous EFS-ADA LV CD34+ cells
Drug: Busulfan
Drug: Peg-Ada

First Posted Date: 2011-06-27

Last Posted Date: 2021-09-16

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 36

Registration Number: NCT01380990

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom

Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis

Not Applicable

Terminated

Conditions: Necrotizing Enterocolitis

Interventions: Procedure: cooling blanket/mattress
Procedure: Standard treatment of care at normothermia

First Posted Date: 2011-04-07

Last Posted Date: 2022-02-03

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 13

Registration Number: NCT01330576

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

Gene Therapy ADA Deficiency

Phase 1

Completed

Conditions: Adenosine Deaminase Deficiency

Interventions: Biological: Intravenous infusion of transduced cells

First Posted Date: 2011-01-19

Last Posted Date: 2015-09-14

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 8

Registration Number: NCT01279720

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

Suicide Gene Therapy Trial

Phase 1

Terminated

Conditions: Haploidentical Stem Cell Transplantation

Interventions: Biological: HSVTK retrovirally-transduced donor T lymphocytes

First Posted Date: 2010-09-17

Last Posted Date: 2013-09-18

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 2

Registration Number: NCT01204502

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)

Not Applicable

Conditions: X-linked Severe Combined Immunodeficiency

Interventions: Genetic: Single infusion of autologous CD34+ cells transduced with the self-inactivating (SIN) gammaretroviral vector pSRS11.EFS.IL2RG.pre

First Posted Date: 2010-08-04

Last Posted Date: 2017-08-01

Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Target Recruit Count: 1

Registration Number: NCT01175239

Locations: 🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

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