Nottingham University Hospitals NHS Trust

🇬🇧United Kingdom

Country: 🇬🇧United Kingdom

Ownership: Private

Established: 2006-01-01

Employees: 10K

Market Cap: -

Website: http://www.nuh.nhs.uk

Clinical Trials

ReAcT CO2: A Study to Assess TcCO2 to Guide Acute NIV

Not Applicable

Not yet recruiting

Conditions: Acute Hypercapnic Respiratory Failure

Interventions: Other: Arterial Blood Gas (ABG) sampling
Device: Trancutaneous CO2 monitoring (using TCM5 device)

First Posted Date: 2023-01-06

Last Posted Date: 2023-01-06

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 60

Registration Number: NCT05674760

REpurposing SirolimUS in Compensated Advanced Chronic Liver Disease. the RESUS Proof of Concept Study

Phase 2

Completed

Conditions: Advanced Chronic Liver Disease

Interventions: Drug: Sirolimus 0.5Mg Tab
Diagnostic Test: 1st MRI scan
Procedure: 1st Percutaneous or Endoscopic Ultrasound guided liver biopsy
Drug: Placebo 0.5mg capsule
Diagnostic Test: Baseline Blood Tests
Diagnostic Test: Baseline Clinical Examination
Diagnostic Test: Week 1 - 5 Titration Blood Tests
Other: Month 2 Clinical Examination
Diagnostic Test: Month 2 Blood Tests
Other: Month 4 Clinical Examination
Diagnostic Test: Month 4 Blood Tests
Other: Month 6 Clinical Examination
Diagnostic Test: Month 6 Blood Tests
Procedure: 2nd Percutaneous or Endoscopic Ultrasound guided liver biopsy

First Posted Date: 2022-12-23

Last Posted Date: 2024-09-30

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 41

Registration Number: NCT05663944

Locations: 🇬🇧
Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom

Understanding Pain Mechanisms in Knee Osteoarthritis

Not Applicable

Not yet recruiting

Conditions: Osteoarthritis, Knee
Chronic Pain

Interventions: Drug: Intra-articular injection of bupivacaine in the knee joint
Drug: Intra-articular injection of placebo in the knee joint

First Posted Date: 2022-09-30

Last Posted Date: 2022-09-30

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 50

Registration Number: NCT05561010

DECISIve - DiagnosE Using the Central veIn SIgn v1.0

Completed

Conditions: Multiple Sclerosis

First Posted Date: 2022-09-09

Last Posted Date: 2024-03-29

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 113

Registration Number: NCT05533905

Locations: 🇬🇧
NUH NHS Trust, Nottingham, United Kingdom

Ursodeoxycholic Acid in C. Difficile Infection

Not Applicable

Terminated

Conditions: Clostridioides Difficile Infection

Interventions: Drug: Ursodeoxycholic acid

First Posted Date: 2022-09-02

Last Posted Date: 2024-04-09

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 6

Registration Number: NCT05526807

Locations: 🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution

Recruiting

Conditions: Pulmonary Nodule, Solitary
Pulmonary Nodule, Multiple
AI (Artificial Intelligence)
Lung Cancer

First Posted Date: 2022-05-25

Last Posted Date: 2025-04-08

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 2000

Registration Number: NCT05389774

Locations: 🇬🇧
University College London Hospitals NHS Foundation Trust, London, United Kingdom
🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
🇬🇧
The Royal Marsden NHS Foundation Trust, London, United Kingdom

and more 7 locations

Complete Vocal Technique Voice Therapy for Muscle Tension Dysphonia (CVT4MTD)

Not Applicable

Conditions: Muscle Tension Dysphonia

Interventions: Behavioral: Complete Vocal Technique Voice Therapy

First Posted Date: 2022-05-09

Last Posted Date: 2022-05-09

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 10

Registration Number: NCT05365126

Locations: 🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom

Nutrition and Metabolic Prehabilitation in HSCT Patients UK and ROI. BSBMT Multi-centre Survey.

Completed

Conditions: Haematological Malignancy
Bone Marrow Transplant Complications
Stem Cell Transplant Complications
Nutrition Aspect of Cancer
Nutritional and Metabolic Disease
Exercise Interventions
Prehabilitation

First Posted Date: 2022-04-29

Last Posted Date: 2023-10-05

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 66

Registration Number: NCT05352789

Locations: 🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom

Median Nerve Stimulation for Tourette Syndrome and Chronic Tic Disorder

Not Applicable

Completed

Conditions: Chronic Tic Disorder
Tourette Syndrome

Interventions: Device: Sham stimulation
Device: Active stimulation

First Posted Date: 2022-03-08

Last Posted Date: 2023-03-13

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 132

Registration Number: NCT05269953

Locations: 🇬🇧
Sir Colin Campbell Building, Nottingham, Nottinghamshire, United Kingdom

CFTR Modulators and Gastrointestinal Complications

Completed

Conditions: Distal Intestinal Obstruction Syndrome
Cystic Fibrosis
Pancreatic Disease
Lung Diseases
Digestive System Disease
Gastrointestinal System Disease
Pancreatic Enzyme Abnormality

Interventions: Other: No intervention

First Posted Date: 2022-02-24

Last Posted Date: 2024-07-03

Lead Sponsor: Nottingham University Hospitals NHS Trust

Target Recruit Count: 47023

Registration Number: NCT05253859

Locations: 🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

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