Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults
Phase 1
Completed
- Conditions
- Malaria
- Interventions
- Biological: PfSPZ Challenge
- First Posted Date
- 2013-01-18
- Last Posted Date
- 2016-04-04
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT01771848
- Locations
- 🇪🇸
CRESIB, Hospital ClÃnic-Universitat de Barcelona, Barcelona, Spain
🇪🇸Centre d'Investigació del Medicament Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Phase 1
Completed
- Conditions
- MalariaPlasmodium Falciparum
- Interventions
- Biological: Normal Saline (NS)Biological: PfSPZ Challenge
- First Posted Date
- 2012-11-20
- Last Posted Date
- 2017-05-15
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 30
- Registration Number
- NCT01728701
- Locations
- 🇳🇱
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults
Phase 1
Completed
- Conditions
- Malaria
- Interventions
- Biological: PfSPZ Challenge
- First Posted Date
- 2012-06-21
- Last Posted Date
- 2016-04-04
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 30
- Registration Number
- NCT01624961
- Locations
- 🇩🇪
Eberhard Karls University of Tübingen, Germany, Tübingen, Germany
Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults
Phase 1
Completed
- Conditions
- Malaria
- Interventions
- Biological: PfSPZ ChallengeBiological: Saline
- First Posted Date
- 2012-02-29
- Last Posted Date
- 2014-09-10
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 30
- Registration Number
- NCT01540903
- Locations
- 🇹🇿
Bagamoyo Research and Training Center, Ifakara Health Institute, Bagamoyo, Tanzania
Experimental Human Malaria Infection by PfSPZ
Phase 1
Completed
- Conditions
- Malaria
- Interventions
- Biological: PfSPZ Challenge
- First Posted Date
- 2010-03-15
- Last Posted Date
- 2015-04-21
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 18
- Registration Number
- NCT01086917
- Locations
- 🇳🇱
Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Clinical Trial of the PfSPZ Vaccine
Phase 1
Completed
- Conditions
- Plasmodium Falciparum
- Interventions
- Biological: Plasmodium falciparum Sporozoite (strain NF-54; Anopheles stephensi mosquitoes) Vaccine, Live, Inactivated (gamma irradiation)
- First Posted Date
- 2009-10-26
- Last Posted Date
- 2014-09-10
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 80
- Registration Number
- NCT01001650
- Locations
- 🇺🇸
The Center for Vaccine Development, University of Maryland (CVD/UMB), Baltimore, Maryland, United States
🇺🇸Naval Medical Research Center (NMRC) Clinical Trials Center, on the campus of the National Naval Medical Center (NNMC), Bethesda, Maryland, United States
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