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Found 4 clinical trials|View Analysis
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EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Phase 3
Active, not recruiting
Conditions
Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Metastatic Anal Squamous Cell Carcinoma
Recurrent Anal Squamous Cell Carcinoma
Stage III Anal Cancer AJCC v8
Stage IV Anal Cancer AJCC v8
Unresectable Anal Squamous Cell Carcinoma
Interventions
First Posted Date
2020-06-24
Last Posted Date
2024-12-27
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
205
Registration Number
NCT04444921
Locations
🇺🇸

Idaho Urologic Institute-Meridian, Meridian, Idaho, United States

🇺🇸

Trinity Health Medical Center - Canton, Canton, Michigan, United States

🇺🇸

Caro Cancer Center, Caro, Michigan, United States

and more 580 locations

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Phase 2
Recruiting
Conditions
Stage I Anal Cancer AJCC v8
Stage IIA Anal Cancer AJCC v8
Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Anal Canal Squamous Cell Carcinoma
Anal Margin Squamous Cell Carcinoma
Interventions
Drug: Capecitabine
Drug: Fluorouracil
Radiation: Intensity-Modulated Radiation Therapy
Drug: Mitomycin
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
First Posted Date
2019-11-18
Last Posted Date
2024-08-07
Lead Sponsor
ECOG-ACRIN Cancer Research Group
Target Recruit Count
252
Registration Number
NCT04166318
Locations
🇺🇸

Alaska Breast Care and Surgery LLC, Anchorage, Alaska, United States

🇺🇸

Providence Alaska Medical Center, Anchorage, Alaska, United States

🇺🇸

Fairbanks Memorial Hospital, Fairbanks, Alaska, United States

and more 649 locations

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Phase 3
Active, not recruiting
Conditions
Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Anal Margin Squamous Cell Carcinoma
Stage IIB Anal Cancer AJCC v8
Stage III Anal Cancer AJCC v8
Interventions
Procedure: Biospecimen Collection
Procedure: Biopsy
Procedure: Colonoscopy
Procedure: Computed Tomography
Procedure: Digital Rectal Examination
Procedure: High Resolution Anoscopy
Procedure: Magnetic Resonance Imaging
Other: Patient Observation
Biological: Nivolumab
Procedure: Proctoscopy
Procedure: Sigmoidoscopy
Procedure: X-Ray Imaging
First Posted Date
2017-07-31
Last Posted Date
2024-12-27
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
344
Registration Number
NCT03233711
Locations
🇺🇸

Denver Health Medical Center, Denver, Colorado, United States

🇺🇸

Kaiser Permanente-Franklin, Denver, Colorado, United States

🇺🇸

National Jewish Health-Main Campus, Denver, Colorado, United States

and more 900 locations

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer

Phase 2
Active, not recruiting
Conditions
Anal Basaloid Carcinoma
Stage IV Anal Canal Cancer
Recurrent Anal Canal Carcinoma
Anal Squamous Cell Carcinoma
Metastatic Anal Canal Carcinoma
Stage IIIB Anal Canal Cancer
Anal Canal Cloacogenic Carcinoma
Interventions
Drug: Capecitabine
Drug: Carboplatin
Other: Laboratory Biomarker Analysis
Drug: Cisplatin
Drug: Fluorouracil
Drug: Paclitaxel
Other: Quality-of-Life Assessment
First Posted Date
2015-09-25
Last Posted Date
2023-06-22
Lead Sponsor
ECOG-ACRIN Cancer Research Group
Target Recruit Count
91
Registration Number
NCT02560298
Locations
🇺🇸

ECOG-ACRIN Cancer Research Group, Philadelphia, Pennsylvania, United States

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