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Human Models of Selective Insulin Resistance: Pancreatic Clamp

Phase 1
Not yet recruiting
Conditions
Insulin Resistance
Hyperinsulinemia
Metabolic Dysfunction Associated Steatotic Liver Disease
Non-Alcoholic Fatty Liver Disease
Prediabetic State
Obesity
Interventions
Drug: Insulin human
Drug: Octreotide Acetate
Drug: Glucagon
Drug: Growth Hormone, Human
Drug: 20% D-glucose (aq)
Diagnostic Test: [6,6-2H2] D-glucose
Diagnostic Test: [1-13C1] sodium acetate
Dietary Supplement: Nestle BOOST Plus
Dietary Supplement: KIND Bar
Device: Harvard Apparatus PHD ULTRA CP syringe pump
Device: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
First Posted Date
2024-08-16
Last Posted Date
2025-01-08
Lead Sponsor
Columbia University
Target Recruit Count
36
Registration Number
NCT06558422
Locations
🇺🇸

Columbia University Irving Medical Center, New York, New York, United States

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