Glucagon
- Generic Name
- Glucagon
- Brand Names
- Baqsimi, Glucagen, Gvoke, Ogluo
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 16941-32-5
- Unique Ingredient Identifier
- 76LA80IG2G
- Background
Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia. Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.
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- Indication
Glucagon is indicated as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.
- Associated Conditions
- Severe Hypoglycemia
- Associated Therapies
- -
Research Study in Japan to Compare Dasiglucagon With Glucagon in Treating Very Low Levels of Blood Sugar in Asian Adults With Type 1 Diabetes and Testing of Dasiglucagon for the Same Condition in Japanese Adolescents
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 38
- Registration Number
- NCT06588504
- Locations
- 🇯🇵
Hakata Clinic, Fukuoka, Japan
Human Models of Selective Insulin Resistance: Pancreatic Clamp
- Conditions
- Interventions
- Drug: Insulin humanDrug: Octreotide AcetateDrug: GlucagonDrug: Growth Hormone, HumanDrug: 20% D-glucose (aq)Diagnostic Test: [6,6-2H2] D-glucoseDiagnostic Test: [1-13C1] sodium acetateDietary Supplement: Nestle BOOST PlusDietary Supplement: KIND BarDevice: Harvard Apparatus PHD ULTRA CP syringe pumpDevice: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
- First Posted Date
- 2024-08-16
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 36
- Registration Number
- NCT06558422
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.
- First Posted Date
- 2024-02-09
- Last Posted Date
- 2024-02-12
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 25
- Registration Number
- NCT06252493
- Locations
- 🇺🇸
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States
Dexamethasone/Pancreatic Clamp P&F
- Conditions
- Interventions
- Drug: Insulin humanDrug: Octreotide AcetateDrug: GlucagonDrug: Human Growth HormoneDrug: Dexamethasone OralOther: [6,6-2H2] D-glucoseDrug: 20% D-glucose (aq)Dietary Supplement: BOOST PlusDevice: Harvard Apparatus PHD ULTRA CP syringe pumpDevice: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate AnalyzerOther: Normal salineOther: Human albumin
- First Posted Date
- 2023-11-13
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- Columbia University
- Registration Number
- NCT06126354
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1
- First Posted Date
- 2023-07-25
- Last Posted Date
- 2023-07-25
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT05960565
- Locations
- 🇳🇴
Department of Endocrinology, St. Olavs Hospital, Trondheim, Norway
Pancreatic Clamp in NAFLD
- Conditions
- Interventions
- Drug: Insulin humanDrug: Octreotide AcetateDrug: GlucagonDrug: Growth Hormone, HumanOther: [6,6-2H2] D-glucoseDrug: 20% D-glucose (aq)Dietary Supplement: BOOST PlusDietary Supplement: CORE BarDevice: Harvard Apparatus PHD ULTRA CP syringe pumpDevice: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
- First Posted Date
- 2023-02-13
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 42
- Registration Number
- NCT05724134
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
- Conditions
- Interventions
- Drug: insulin humanDrug: EpinephrinProcedure: Muscle biopsyProcedure: Adipose tissue biopsyDrug: GlucagonDevice: IPRO 2 Medtronic MinimedProcedure: 7 Tesla (7T) Magnetic Resonance ImagingProcedure: Indirect Calorimetry using Jaeger Oxycon ChampionProcedure: Core temperature and thermography using Thermovision SC645Device: Freestyle Libre 2
- First Posted Date
- 2021-10-27
- Last Posted Date
- 2023-05-03
- Lead Sponsor
- Nordsjaellands Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05095259
- Locations
- 🇩🇰
Nordsjaellands Hospital, Hillerød, Denmark
🇩🇰Steno Diabetes Center Copenhagen, Gentofte, Denmark
Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
- First Posted Date
- 2021-07-02
- Last Posted Date
- 2022-08-18
- Lead Sponsor
- Steno Diabetes Center Copenhagen
- Target Recruit Count
- 11
- Registration Number
- NCT04949867
- Locations
- 🇩🇰
Steno Diabetes Center Copenhagen, Gentofte, Denmark
🇩🇰Herlev Hospital, Herlev, Denmark
The Effect of Lifestyle-induced Hepatic Steatosis on Glucagon-stimulated Amino Acid Turnover
- Conditions
- Interventions
- First Posted Date
- 2021-04-26
- Last Posted Date
- 2023-05-11
- Lead Sponsor
- Malte Palm Suppli, MD
- Target Recruit Count
- 20
- Registration Number
- NCT04859322
- Locations
- 🇩🇰
Center for Clinical Metabolic Research, Hellerup, Copenhagen, Denmark
A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes
- Conditions
- Interventions
- First Posted Date
- 2021-01-15
- Last Posted Date
- 2021-01-15
- Lead Sponsor
- Abvance Therapeutics
- Target Recruit Count
- 15
- Registration Number
- NCT04712266
- Locations
- 🇺🇸
Atlanta Diabetes Associates, Atlanta, Georgia, United States
Drug Development Updates
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