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Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

Phase 2
Terminated
Conditions
Refractory Malignant Peripheral Nerve Sheath Tumor
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Neuroblastoma
Recurrent Rhabdomyosarcoma
Refractory Malignant Solid Neoplasm
Desmoplastic Small Round Cell Tumor
Recurrent Malignant Peripheral Nerve Sheath Tumor
Refractory Desmoplastic Small Round Cell Tumor
Recurrent Desmoplastic Small Round Cell Tumor
Recurrent Malignant Solid Neoplasm
Interventions
First Posted Date
2020-08-28
Last Posted Date
2024-10-26
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
40
Registration Number
NCT04530487
Locations
🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients

Early Phase 1
Active, not recruiting
Conditions
Malignant Pelvic Neoplasm
Recurrent Gastric Carcinoma
Recurrent Liposarcoma
Recurrent Ovarian Carcinoma
Recurrent Rhabdomyosarcoma
Refractory Colon Carcinoma
Malignant Abdominal Neoplasm
Refractory Ovarian Carcinoma
Recurrent Colon Carcinoma
Recurrent Desmoplastic Small Round Cell Tumor
Interventions
Drug: Cisplatin
Procedure: Cytoreductive Surgery
Drug: Doxorubicin
Drug: Hyperthermic Intraperitoneal Chemotherapy
Drug: Sodium Thiosulfate
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography
Procedure: Biospecimen Collection
First Posted Date
2019-12-30
Last Posted Date
2024-08-26
Lead Sponsor
Mayo Clinic
Target Recruit Count
2
Registration Number
NCT04213794
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

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