DRKS00008014尚未招募未知
Synaptic mechanisms of therapeutic sleep deprivation in major depression
niversitätsklinikum FreiburgKlinik für Psychiatrie und Psychotherapie0 个研究点目标入组 45 人开始时间: 2015年4月16日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Ages = 18 = 65
- •Ability to provide informed consent
- •normal or corrected-to-normal vision
- •Absence of any exclusion criteria
- •Major depressive disorder (ICD-10: F32.2 and F33.2)
- •Score of =15 on the 21-item Hamilton Rating Scale for Depression (HAMD)
排除标准
- •Neurological disorders including epilepsy, history of brain injury, encephalitis, or any organic brain syndrome
- •metallic implants
- •present pregnancy
- •DSM-V axis I disorder (lifetime) apart from major depression, such as schizophrenia, schizoaffective disorder, any non-bipolar psychotic disorder, bipolar disorders, primary anxiety or obsessive compulsive disorder, mental retardation, signs of impaired cognitive functioning
- •Lifetime history for drug/alcohol dependence, or drug/alcohol abuse within the past year
- •Medication with any anxiolytic or antipsychotic drug, except antidepressants for patients
- •Medical conditions including severe cardiac, liver, kidney, endocrine (e.g., diabetes), hematologic disorders (e.g., porphyria or any bleeding abnormalities), other impairing or unstable medical condition or impending surgery
- •Primary sleep disorders diagnosed according to DSM-V criteria.
- •Inability to read or understand the study forms and agree to informed consent.
- •Irregular sleep schedules associated with shift work, frequent travel, or personal preference as indicated by weekly variation of >3 hours in bed time or wake time, or sleep duration <5.5 or > 10 hours per night.
- •Left-handedness
- •Acute suicidality
- •Psychotic features of MDD
- •Excessive use of caffeine (>300 mg or three cups of coffee per day).
- •Excessive smoking (>10 cigarettes/day).
研究者
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