Effect of Non Surgical Periodontal therapy in patients with Periodontitis and Type 2 Diabetes Mellitus

Haldia Institute of dental sciences and research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年8月21日

试验速览

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•Subjects with Gingivitis : full mouth bleeding on probing less than 10% of sites.
•Subjects with Periodontitis : Subjects with Periodontitis with interdental clinical attachment
•loss detectable at >- 2 non adjacent teeth .Buccal or oral clinical attachment loss >-3 mm
•with pocketing > 3mm is detectable at >-2 teeth.
•Subjects with Periodontally Healthy (PH) : Subjects with PH will have no history of periodontitis, no sites with PD and CAL > 3 mm concurrently and no more than 10% of the sites with gingival bleeding and/or BoP.
•Diabetic subjects :The diabetic subjects will require a diagnosis of DM confirmed by a physician, dating from at least 2 years prior to the study. In addition, all diabetic patients will be required to have a HbA1c > 6.5% and FPG > 99 mg/dl.
•Non-diabetics: Non-diabetic subjects will have no history of DM, HbA1c = 6.0% and FPG < 99 mg/dl.

•Pregnancy; breastfeeding; subgingival periodontal therapy during the previous 12 months; use of antibiotic, anti-inflammatory, and/or immunosuppressive therapies during the previous 6 months; regular use of mouthrinses containing antimicrobials; use of orthodontic
•appliances; presence of other infectious, immunological, and/or inflammatory systemic conditions (e.g., immunological disorders, rheumatoid arthritis) and major complications of DM (i.e.,ulcers, gangrene, amputation, neuropathy, and nephropathy),smokers.

发起方

Haldia Institute of dental sciences and research