Can Genetic Changes Predict Weight Loss and Outcome After Bariatric Surgery and Can it Related to Virus Infection and Function of Liver and Adipose Tissue as Well as Lipid and Protein Profiles.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,000
- 试验地点
- 3
- 主要终点
- Genetic markers
研究概览
简要总结
There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •laparoscopic gastric by-pass with BMI greater than 35
排除标准
- •unable to understand swedish
结局指标
主要结局
Genetic markers
时间窗: day of surgery and 1 and 2 years after surgery
Blood samples and tissue biopsies taken at the time of surgery and at follow-up.
次要结局
- Genexpression and comorbid disease(At time of bariatric surgery and 1-2 years postoperatively)
- Lipid and protein patterns in plasma and tissues(day of surgery and at 1 and 2 years postoperatively)
- Previous viral infection(At time of surgery)
研究者
Erik Näslund
Professor
Karolinska Institutet