Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).
研究概览
简要总结
The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured data to answer the following questions:
What level of positive end expiratory pressure (PEEP) causes a HFNO with different flow rates? Does HFNO work as pressure support or does it act more like a Continuous Positive Airway Pressure (CPAP) ventilation?
详细描述
High Flow Oxygen through nasal cannula is widely used in the setting of hypoxemic respiratory failure of heterogenous etiology with very good patients compliance.
However, the evidence of what level of PEEP or pressure support (if any) with different flow rates is weak.
Our goal is to determine these effects and compare them with standard approach with non-invasive ventilation via full face mask.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers willing to participate
排除标准
- •general contraindications for oesophageal catheter insertion: oesophageal varices, bleeding disorders (including anticoagulant medication), diverticulitis, oesophageal tumors, history of recent oesophageal/gastric surgery, recent epistaxis,
- •sinusitis
- •allergy to local anesthetics
- •subject refusal
研究组 & 干预措施
Experimental group
10-12 young healthy volunteers. Placed on semi-sitting position on the bed (40 deg.elevation). Calibration of electrical impedance tomography (EIT) on defined tidal volume 500ml, done with 500ml syringe connected to closed breathing circuit using full face mask as an interface.
Insertion an esophageal and nasopharyngeal catheter for pressures measurement. In the first phase - spontaneous breathing with full face mask at 0, 5 and 10 cm H20 levels of PEEP.
In the second phase - high flow oxygenation through nasal cannula, start with flow rate 10 L/min with gradual increase up to 60 L/min.
Spirometry to determine functional residual capacity (FRC) before and after procedure is planed.
干预措施: High Flow Nasal generator (AirVO2) (Device)
结局指标
主要结局
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).
时间窗: 1 hour
Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20 on conventional NIV.
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on High flow nasal oxygenation (HFNO).
时间窗: 1 hour
Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20) on High flow nasal oxygenation (HFNO).
Monitoring of EIT during spontaneous ventilation with High flow nasal oxygenation (HFNO).
时间窗: 1 hour
EIT for description of distribution of ventilation with HFNO with different flow rate levels (litres per minute).
Monitoring of EIT during spontaneous ventilation on conventional non-invasive ventilation (NIV).
时间窗: 1 hour
EIT for description of distribution of ventilation on conventional NIV at different levels of PEEP (cm H20).
Calculation of Pressure Time Product (PTP) for estimation of Work of Breathing (WOB).
时间窗: up to 8 weeks
Compare PTP between conventional NIV and HFNO.
次要结局
未报告次要终点