Optical Coherence Tomography Angiography in Neurological Disease: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Vascular and Perfusion Density in healthy controls
研究概览
简要总结
Optical Coherence Tomography Angiography (OCTA) is a non-invasive tool that images the neurovascular structures of the eye by using near-infrared light. Previous literature has demonstrated the potential of OCTA as a screening tool in stroke, but its utility in other neurological illness such as intracranial hemorrhage is unclear. Hence, this pilot study will gather preliminary data to support future grant applications to investigate this area more fully by recruiting patients with neurological illness and healthy controls and comparing their OCTA imaging parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years or older
- •Patient admitted to the neuroscience intensive care unit with a diagnosis of: subarachnoid hemorrhage, intracerebral hemorrhage, intracranial aneurysm (ruptured or unruptured), intracranial vascular malformation, ischemic stroke, seizure disorder, intracranial infection, intracranial tumor(s), inflammatory demyelinating disease, traumatic brain injury and/or neuromuscular respiratory failure OR subjects from the community without major neurologic, cardiovascular, pulmonary or metabolic disease
排除标准
- •Pregnancy
- •Non-English speaking
- •GCS motor score less than 6 (i.e. must be able to follow commands)
- •Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device
研究组 & 干预措施
Control
Normal healthy human subjects
干预措施: OCTA (Device)
Patients
Patients with neurological disease
干预措施: OCTA (Device)
结局指标
主要结局
Vascular and Perfusion Density in healthy controls
时间窗: Once (approx. 10 mins)
Quantitative measure of retinal microperfusion. No definite time points are defined since different neurological diseases have different patterns of evolution and patient/provider availability may change.
Vascular and Perfusion Density in Patients with neurological disease
时间窗: Throughout study completion up to 28 days
Quantitative measure of retinal microperfusion. No definite time points are defined since different neurological diseases have different patterns of evolution and patient/provider availability may change.
次要结局
未报告次要终点
研究者
Noah Jouett
Assistant Professor
University of Texas Southwestern Medical Center