Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Overall outcomes in CADASIL patients
研究概览
简要总结
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sign informed consent.
- •Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
- •Asymptomatic NOTCH3 mutation carriers
- •Relatives of CADASIL patients or carriers
- •Unrelated healthy controls
排除标准
- •Unable to cooperate with inspectors
- •Serious systemic illness, such as heart, liver, kidney disease or major mental illness
- •Contraindications for imaging examination
结局指标
主要结局
Overall outcomes in CADASIL patients
时间窗: From date of enrollment until the date of death from any cause, assessed up to 20years
record the occurrence of stroke and use modified Rankin Scale (mRS) to measure the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability.
次要结局
- The correlation of genotype and phenotype(From date of enrollment until the date of death from any cause, assessed up to 20years)
研究者
Bin Cai
Professor
First Affiliated Hospital of Fujian Medical University