Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degenerative Mitral Regurgitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- MR 2+ or more recurrency
研究概览
简要总结
Mitral regurgitation is a pathology affecting the left atrioventricular valve that causes a volumetric and pressure overload in the left chambers due to the loss of unidirectionality normally guaranteed by the cardiac valve system. The gold standard for severe mitral regurgitation is currently mitral valve plastic surgery.
Edge to edge, on the other hand, allows shorter CEC and aortic clamping times and does not require significant surgical experience in the field of mitral valve repair, therefore edge to edge could be an excellent strategy in patients suffering from mitral regurgitation caused by P2 prolapse when quadrangular resection cannot be performed.
The main objective of the present study is to examine the medium to long-term outcomes (in terms of survival and plastic outcomes) of patients undergoing central edge-to-edge to treat posterior flap pathology (P2).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mitral regurgitation with degenerative etiology
- •Mitral pathology exclusively dependent on P2
- •Surgical creation of a double mitral valve orifice with or without a ring as the only mitral valve repair technique.
排除标准
- •Other mitral regurgitation etiologies (eg. functional, radiation-induced, rheumatic...)
结局指标
主要结局
MR 2+ or more recurrency
时间窗: through study completion, a minimum of 2 years
次要结局
- Reintervention(through study completion, a minimum of 2 years)
研究者
Michele De Bonis
Chief od Cardiac Surgery of Advanced and Research Therapies
Ospedale San Raffaele