The effect of synbiotic consumption on serum NTproBNP, hsCRP and blood pressure in patients with heart failure

Iran University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2019年11月5日

适应症

试验速览

暂无简介。

•Age range from 30 to 70 years
•Patients with systolic heart failure (LVEF <40%) approved by a cardiologist and receiving at least 3 months of standard heart failure treatment , Medications have reached the maximum tolerated dose and their medication dose will remain constant throughout the study.
•class 1,2 and 3 of NYHA classification
•Willingness to participate in the study and sign informed written consent
•Lack of other diseases including chronic and acute liver disorders (hepatitis B, C, etc.), diabetes, thyroid disorders, severe renal dysfunction (300 mmol /l = creatinine ), pulmonary diseases, inflammatory and autoimmune diseases, Cancer, acute infection
•Not using any nutritional supplements for the past two months.
•No substance abuse and smoking
•Not taking Corticosteroids in the past 4 weeks
•Failure to receive antibiotics in the past 3 months
•No history of gastrointestinal surgery
•No anti-inflammatory drugs except low-dose aspirin (one 80 mg daily)
•No artificial heart valve
•No history of rheumatic heart disease
•Not being pregnant and breastfeeding
•Lack of insulin

•Not willing to continue cooperation
•use of less than 80% of supplements given to the patient during the study period Acceptance rate = The number of capsules given to the patient - the Number of capsules not used / The number of capsules given to the patient
•other disease such as metabolic diseases,Cancer and inflammatory diseases during the study that Need special treatment or antibiotic use.
•Changes in the type and dose of drug which is using by the patient .

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