Muscle Oxygenation and Metabolism in Response to a Localized Fatigue-inducing Exercise in Patients With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Muscle deoxygenation
研究概览
简要总结
The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
- •Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
- •Smoking history > 15 pack-years
排除标准
- •Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
- •Recent exacerbation (< 3 months)
- •Recent cancer (< 3 years)
- •Myopathy, neuromuscular or articular disease
- •Unstable cardiac disease
- •Absolute contraindications to exercise testing
- •Regular physical activity or exercise training program in the last 2 months
- •Physical activity score > 9 in the Voorips questionnaire
- •Thigh skinfold thickness > 15 mm
- •BMI > 30
结局指标
主要结局
Muscle deoxygenation
时间窗: 45 seconds post-exercise (knee-extension repetitions)
Changes of deoxyhemoglobin/myoglobin concentrations measured by near-infrared spectroscopy of vastus lateralis muscle.
Muscle metabolism
时间窗: 45 seconds post-exercise (knee extension repetitions)
Changes in glycolytic and oxidative metabolism pathway markers, energy substrates (glycogen and glucose), end-products of glycolysis (pyruvate, and lactate), intermediate markers of glycolysis and high-energy phosphate compounds obtained from muscle biopsies
次要结局
- Ventilatory response(Baseline, beginning and end of each serie of knee extensions (fatiguing exercise))
- total muscle work(end of fatiguing exercise)
- Quadriceps muscle fatigue(baseline, 15 min and 40 min after the fatigue-inducing exercise)
研究者
Fernanda Ribeiro
PhD candidate
Laval University