Effects of Acute Glucose and Fructose Ingestion on Brain Activity in Obese Volunteers

University Hospital, Basel, Switzerland0 个研究点目标入组 12 人开始时间: 2013年10月1日最近更新: 2015年10月28日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 12
主要终点: Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Prevention
盲法: Double (Participant, Investigator)

入排标准

年龄范围: 18 Years 至 45 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•right-handed healthy males, no drugs, non-smoking

排除标准

•drug abuse, smoker, left-handed, claustrophobia

结局指标

主要结局

Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow

时间窗: changes from baseline to one hour after treatment

次要结局

Changes in plasma insulin(changes from baseline to one hour after treatment)
Changes in plasma GLP-1(changes from baseline to one hour after treatment)
Changes in plasma glucose(changes from baseline to one hour after treatment)

研究者

发起方

University Hospital, Basel, Switzerland

申办方类型

Other

责任方

Sponsor

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