Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Regional ventilation
研究概览
简要总结
In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •need for mechanical ventilation due to respiratory failure after cardiac surgery
排除标准
- •circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support
结局指标
主要结局
Regional ventilation
时间窗: 6 hours
Regional distribution of ventilation over 6 hours of treatment
次要结局
- arterial oxygenation and inflammation(6 hours)
