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临床试验/NCT01280019
NCT01280019Unknown4 期

Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery

University of Luebeck2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2010年10月1日最近更新:
适应症

试验速览

阶段
4 期
发起方
入组人数
20
试验地点
2
主要终点
Regional ventilation

研究概览

简要总结

In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • need for mechanical ventilation due to respiratory failure after cardiac surgery

排除标准

  • circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support

结局指标

主要结局

Regional ventilation

时间窗: 6 hours

Regional distribution of ventilation over 6 hours of treatment

次要结局

  • arterial oxygenation and inflammation(6 hours)

研究者

发起方
University of Luebeck
申办方类型
Other

研究点 (2)

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