Combined Effects of Dietary Supplementation With Dietary Resistant Starch (RS) and Whey Protein on Resting Energy Expenditure and Blood Sugar and Insulin Responses in Lean and Obese Men and Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Change in fat oxidation from Baseline to 180 Minutes Postprandial
研究概览
简要总结
Recent evidence shows that dietary supplementation with resistant starch (RS) increases fat catabolism and resting energy expenditure and decreases plasma insulin and glucose responses as well as the gut-derived hormone, glucose-dependent insulinotropic polypeptide (GIP). Consumption of whey protein has also been shown to increase energy expenditure and favorably affect gut hormones. Thus, investigators tested consumption of both RS and whey protein on energy expenditure and gut hormones in lean and obese women and men.
详细描述
Consumed separately, resistant starch (RS) and whey protein (WP) favorably affect energy metabolism and gut hormones, as well as suppress feelings of hunger. These findings are important because release of certain gut hormones (i.e., GIP) is associated with a lower resting energy expenditure (REE) in healthy humans. Interestingly, a recent study showed that ingestion of RS reduces postprandial GIP and increases postprandial REE and fat utilization in healthy men and therefore may be an effective strategy in weight management. Thus, there is a need to replicate these findings in a healthy cohort of lean and obese women and men.
The purpose of this study was to examine the effects of RS on the number of calories burned after eating a meal, as well as specific hormones that are released from the stomach and intestines following meal ingestion in healthy lean and obese women and men. Investigators used a single ingestion of a meal supplemented with or without the resistant starch and whey protein.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •overweight or lean but otherwise healthy
排除标准
- •Participants will be excluded if they smoke; have experienced excessive weight loss/gain of > ±2kg in the previous 2 months; are currently taking medications for cardiovascular or metabolic disease.
研究组 & 干预措施
waxy maize starch
pancake test meal - waxy maize starch
干预措施: waxy maize starch (Other)
waxy maize starch and whey protein
pancake test meal - waxy maize starch and whey protein
干预措施: waxy maize starch (Other)
waxy maize starch and whey protein
pancake test meal - waxy maize starch and whey protein
干预措施: waxy maize starch and Whey Protein (Other)
resistant starch
pancake test meal - resistant starch
干预措施: Resistant Starch (Other)
resistant starch and whey protein
pancake test meal - resistant starch and whey protein
干预措施: Resistant Starch (Other)
resistant starch and whey protein
pancake test meal - resistant starch and whey protein
干预措施: resistant starch and whey protein (Other)
结局指标
主要结局
Change in fat oxidation from Baseline to 180 Minutes Postprandial
时间窗: time 0, 60, 120, 180 minutes
indirect calorimetry of fuel utilization
次要结局
- Change in self-reported feelings of hunger, fullness, satiation from Baseline to 180 Minutes Postprandial(time 0, 60, 120, 180 minutes)
- Change in gut hormones from Baseline to 180 Minutes Postprandial(time 0, 60, 120, 180 minutes)
