The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Growth Differentiation Factor 15
研究概览
简要总结
A key area of obesity research has focused on the link between appetite, energy balance and weight control. Within this area, several appetite-related hormones and cellular cytokines have been identified as key signals influencing appetite and food intake. This includes the appetite-suppressing hormone oxyntomodulin (OXM) and a cellular stress-induced cytokine growth differentiation factor 15 (GDF-15).
The aims of this study are: (1) to investigate the effect of acute moderate-intensity continuous exercise on oxyntomodulin and GDF-15 concentrations; (2) to investigate whether exercise-induced changes in circulating OXM and GDF-15 concentrations are correlated with subjective appetite perceptions and subsequent energy intake.
详细描述
Oxyntomodulin is thought to promote weight loss by suppressing appetite and energy intake and increasing energy expenditure. Acute exercise has been shown to increase the circulating concentration of satiety-related gut hormones, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). However, the effect of acute exercise on OXM concentrations in individuals with healthy weight has not been investigated.
GDF-15 is a cellular stress-induced cytokine which has recently been shown to suppress appetite. A few studies have explored the effect of acute exercise on GDF-15 concentrations but the findings are conflicting. Some studies have shown that acute exercise, which provides a transient physiological stress, increased GDF-15 concentrations, but other studies have not found any influence of exercise on GDF-15 concentrations. In addition, whether post-exercise appetite perceptions and subsequent energy intake are influenced by exercise-related changes in OXM or GDF-15 concentrations remains unknown.
To explore the impact of acute moderate-intensity continuous exercise on OXM and GDF-15 levels, alongside subjective appetite perceptions and subsequent energy intake, all participants in this crossover study engaged in both exercise and control trials, with a minimum one-week interval between each.
During the exercise trial, participants were asked to arrive at the lab at 8.30 am, having fasted overnight for 10 hours (except plain water). Participants were asked to rest in the lab for 30 minutes. During the resting period, a cannula was positioned in the participants' arm and a mask was fitted on the face in the last five minutes of the rest to allow for the collection of exhaled air during exercise. After the resting period, participants were asked to exercise at an intensity of 70 percent of their peak oxygen uptake for an hour before resting in the lab for a further 2.5 hours. Venous blood samples were collected before (0 minutes) and after (60, 90, 120, 150, 180, and 210 minutes) exercise and ad libitum energy intake was assessed 1 h after exercise completion. For the control trial, participants replicated all the procedures of the exercise trial except they rested for 1 h as the exercise counterpart.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index between 18.5-24.9 kg/m²;
- •Habitually consume three meals a day;
- •Able to run continuously for 1 hour;
- •Not currently dieting and weight stable for 3 months (< 3 kg change in weight);
- •No severe dislike or allergy to any of the study food;
- •Regular menstrual cycle in the past 6 months.
排除标准
- •Smokers (vaping is considered smoking in this study);
- •Individuals with medical conditions (e.g., diabetes, heart condition);
- •Individuals taking medications that may influence the study outcomes;
- •Individuals with clinically diagnosed eating disorders.
结局指标
主要结局
Growth Differentiation Factor 15
时间窗: Blood samples were collected for GDF-15 measurements at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.
(pg/mL)
Oxyntomodulin
时间窗: Blood samples were collected for oxyntomodulin measurements at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.
(pmol/L)
次要结局
- Energy intake(Ad libitum pasta meal provided at 120 minutes.)
- Visual analogue score (VAS) for subjective appetite(VAS was measured at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.)
研究者
Professor David Stensel
Professor
Loughborough University