Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Intubating condition
研究概览
简要总结
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 yr
- •scheduled for elective rigid bronchoscopy
排除标准
- •known neuromuscular disease
- •significant hepatic or renal dysfunction
- •family history of malignant hyperthermia
- •known allergy to one of the drugs used in this protocol
- •pregnancy or breastfeeding
研究组 & 干预措施
Succinylcholine
Patient receive succinylcholine as a muscle relaxant (0,5mg/kg) after induction of general anaesthesia for rigid bronchoscopy.
干预措施: Succinylcholine (Drug)
Mivacurium
Patients receive mivacurium (0,08mg/kg) as a muscle relaxant after induction of general anaesthesia for rigid bronchoscopy. At the end of the procedure and a twitch of 25% mivacurium was reversed with neostigmine (50 microg/kg) and atropin (10 microg/kg)
干预措施: Mivacurium (Drug)
结局指标
主要结局
Intubating condition
时间窗: After induction of general anaesthesia (after 3-5 minutes)
For measuring the intubation conditions the scoring system proposed for Good clinical Research Practice using the following variables is used: conditions of inserting the rigid bronchoscope, vocal cord position and coughing
次要结局
- Postoperative Myalgia(72 hours after intervention)
- postintervention performance with a expiration exercise device(72 hours after intervention)