NCT06795984已完成不适用
Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?
Calla IVF Center1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2023年8月12日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success.
研究概览
简要总结
This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients aged 20-40 years.
- •Normal uterine cavity confirmed by hysteroscopy or sonohysterography.
- •At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL).
排除标准
- •uterine abnormalities,
- •systemic autoimmune diseases,
- •severe male infertility factors.
结局指标
主要结局
the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success.
时间窗: 12 months
The value of CD56 NK cell and KIR AA in patients undergoing IVF and pregnancy rate
次要结局
未报告次要终点
研究者
研究点 (1)
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