NCT01847456已完成不适用
Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Insulin sensitivity as measured by clamp
研究概览
简要总结
The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI < 28 kg/m2
- •normal HbA1c
- •healthy volunteers
排除标准
- •Heparin induced thrombocytopenia (HIT)
- •metal implants
- •cardial diseases
- •patients taking any kind of drugs
研究组 & 干预措施
insulin nasal spray
Experimental
160 Units of human insulin as nasal spray
干预措施: human insulin as nasal spray (Drug)
Placebo nasal spray
Placebo Comparator
Nasalspray containing placebo solution
干预措施: Placebo (Drug)
结局指标
主要结局
Insulin sensitivity as measured by clamp
时间窗: 45 minutes to 120 minutes post nasal spray
We will measure insulin sensitivity by hyperinsulinemic euglycemic clamp before and after nasal spray application. We will compare the post-spray insulin sensitivity between the two condition (insulin nasal spray vs placebo nasal spray). Furthermore, we will compare insulin sensitivity before and after nasal insulin application.
次要结局
- Autonomous nervous system activity(45 to 120 minutes post spray)
研究者
andreas fritsche
Professor of Medicine
University Hospital Tuebingen
研究点 (1)
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