Elevated Plasma Levels of TIMP-1 in Patients With Rotator Cuff Tear
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Level of MMP and TIMP in plasma
研究概览
简要总结
The aim of the study was to investigate the levels of matrixmetalloproteinases and their inhibitors in blood samples from patients with rotator cuff tears and compare with blood samples from healthy matched controls.
详细描述
Background: Extracellular matrix remodeling is altered in rotator cuff tears, partly due to altered expression of matrix metalloproteinases (MMPs) and their inhibitors. It is unclear if this altered expression can be traced as changes in plasma protein levels. We measured the plasma level of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears.
Material and methods
Blood samples were collected from 17 patients, median 61 (range 39-77) years, with sonographically verified rotator cuff tears (partial- or full-thickness). These were compared with 16 gender and age matched control persons with sonographically intact rotator cuffs. Plasma levels of MMPs and TIMPs were measured simultaneously using Luminex technology.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •degenerative rotator cuff tear verified by ultrasound
排除标准
- •systemic joint disease such as rheumatoid arthritis
- •a fracture non-union
- •dupuytrens disease
- •frozen shoulder
- •tendinosis or rupture of any other tendons than in the rotator cuff
- •disorders of the spine such as disc disease,idiopathic scoliosis, spondylitis
- •cerebral or cardiovascular disease during the past year
- •abdominal or bowel disease
- •surgery or trauma during the past year
- •any infection during the last month
- •malignancy
- •treatment for the last month with medications that may affect MMPs or TIMPs (tetracycline, bisphosphonates, anti-inflammatory drugs, statins)
- •vigorous physical activity during the last 24 hours
- •inability to understand written and spoken Swedish
结局指标
主要结局
Level of MMP and TIMP in plasma
时间窗: Measaured at one time point
Four mL venous blood samples were collected from all study participants after inclusion, and centrifuged to plasma that was stored at -70 degrees until the analysis.
次要结局
未报告次要终点
研究者
Hanna Bjornsson
MD, Shoulder surgeon and head of shoulder research team
University Hospital, Linkoeping