NCT02493959已完成早期 1 期
Degradation of the Anorexic Hormone Peptide YY
适应症
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Half-lives of PYY1-36 and PYY3-36
研究概览
简要总结
Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal BMI (18.5-25kg/m2)
排除标准
- •Diabetes Mellitus
- •Gastric bypass
- •Non-caucasian
- •Height changes >3 kg within last two months
- •Hemoglobin < 7.6 mmol/l
- •Chronic disease
- •Regularly use of medicine
- •Drug abuse
结局指标
主要结局
Half-lives of PYY1-36 and PYY3-36
时间窗: 0-240 min
PYY3-34 concentration
时间窗: 0-240 min
次要结局
未报告次要终点
研究者
Kirstine Nyvold Bojsen-Moeller
MD
Hvidovre University Hospital
研究点 (2)
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